MRC National Institute for Medical Research, London

Victor Tybulewicz Publications

• Devoy, A; Bunton-Stasyshyn, RKA; Tybulewicz, VLJ; Smith, AJH and Fisher, EMC (2012)
  Genomically humanized mice: technologies and promises.
  Nature Reviews Genetics 13, 14-20 PubMed abstract
• Finney, BA; Schweighoffer, E; Navarro-Núñez, L; Bénézech, C; Barone, F; Hughes, CE; Langan, SA; Lowe, KL; Pollitt, AY; Mourao-Sa, D; Sheardown, S; Nash, GB; Smithers, N; Reis e Sousa, C; Tybulewicz, VLJ and Watson, SP (2012)
  CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
  Blood 119, 1747-1756 PubMed abstract
• Haubert, D; Li, J; Saveliev, A; Calzascia, T; Sutter, E; Metzler, B; Kaiser, D; Tybulewicz, VLJ and Weckbecker, G (2012)
  Vav1 GEF activity is required for T cell mediated allograft rejection.
  Transplant Immunology [Epub ahead of print] PubMed abstract
• Sheppard, O; Plattner, F; Rubin, A; Slender, A; Linehan, JM; Brandner, S; Tybulewicz, VLJ; Fisher, EMC and Wiseman, FK (2012)
  Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
  Neurobiology of Aging 33, 828.e831- 828.e844 PubMed abstract
• Sheppard, O; Wiseman, FK; Ruparelia, A; Tybulewicz, VLJ and Fisher, EMC (2012)
  Mouse models of aneuploidy.
  Scientific World Journal 2012, [Epub ahead of print] PubMed abstract
• Vidaki, M; Tivodar, S; Doulgeraki, K; Tybulewicz, V; Kessaris, N; Pachnis, V and Karagogeos, D (2012)
  Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex.
  Cerebral Cortex 22, 680-692 PubMed abstract
• Cleary, JO; Wiseman, FK; Norris, FC; Price, AN; Choy, M; Tybulewicz, VLJ; Ordidge, RJ; Brandner, S; Fisher, EMC and Lythgoe, MF (2011)
  Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.
  Neuroimage 56, 974-983 PubMed abstract
• da Gloria Sousa, M; Reid, DM; Schweighoffer, E; Tybulewicz, V; Ruland, J; Langhorne, J; Yamasaki, S; Taylor, PR; Almeida, SR and Brown, GD (2011)
  Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
  Cell Host & Microbe 9, 436-443 PubMed abstract
• Duchon, A; Pothion, S; Brault, V; Sharp, AJ; Tybulewicz, VLJ; Fisher, EMC and Herault, Y (2011)
  The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.
  Behavioural Brain Research 217, 271-281 PubMed abstract
• Lana-Elola, E; Watson-Scales, SD; Fisher, EMC and Tybulewicz, VLJ (2011)
  Down syndrome: searching for the genetic culprits.
  Disease Models & Mechanisms 4, 586-595
• Singleton, KL; Gosh, M; Dandekar, RD; Au-Yeung, BB; Ksionda, O; Tybulewicz, VLJ; Altman, A; Fowell, DJ and Wülfing, C (2011)
  Itk controls the spatiotemporal organization of T cell activation.
  Science Signaling 4, ra66 PubMed abstract
• Alford, K; Slender, A; Vanes, L; Li, Z; Fisher, EMC; Nizetic, D; Orkin, SH; Roberts, I and Tybulewicz, VLJ (2010)
  Perturbed hematopoiesis in the Tc1 mouse model of Down Syndrome.
  Blood 115, 2928-2937 PubMed abstract
• Anderson, KE; Chessa, TAM; Davidson, K; Henderson, RB; Walker, S; Tolmachova, T; Grys, K; Rausch, O; Seabra, M; Tybulewicz, VLJ; Stephens, LR and Hawkins, PT (2010)
  PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.
  Blood 116, 4978-4989 PubMed abstract
• D'Amico, G; Robinson, SD; Germain, M; Reynolds, LE; Thomas, GJ; Elia, G; Saunders, G; Fruttiger, M; Tybulewicz, V; Mavria, G and Hodivala-Dilke, KM (2010)
  Endothelial-Rac1 is not required for tumor angiogenesis unless αvβ3-integrin is absent.
  PLoS ONE 5, e9766 PubMed abstract
• De Vita, S; Canzonetta, C; Mulligan, C; Delom, F; Groet, J; Baldo, C; Vanes, L; Dagna-Bricarelli, F; Hoischen, A; Veltman, J; Fisher, EMC; Tybulewicz, VLJ and Nizetic, D (2010)
  Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.
  Oncogene 29, 6102-6114 PubMed abstract
• Dunlevy, L; Bennett, M; Slender, A; Lana-Elola, E; Tybulewicz, VL; Fisher, EMC and Mohun, T (2010)
  Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.
  Cardiovascular Research 88, 287-295 PubMed abstract
• Faroudi, M; Hons, M; Zachacz, A; Dumont, C; Lyck, R; Stein, JV and Tybulewicz, VLJ (2010)
  Critical roles for Rac GTPases in T cell migration to and within lymph nodes.
  Blood 116, 5536-5547 PubMed abstract
• Henderson, RB; Grys, K; Vehlow, A; de Bettignies, C; Zachacz, A; Henley, T; Turner, M; Batista, F and Tybulewicz, VLJ (2010)
  A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
  Journal of Experimental Medicine 207, 837-853 PubMed abstract
• Mócsai, A; Ruland, J and Tybulewicz, VLJ (2010)
  The SYK tyrosine kinase: a crucial player in diverse biological functions.
  Nature Reviews Immunology 10, 387-402 PubMed abstract
• Reynolds, LE; Watson, AR; Baker, M; Jones, TA; D'Amico, G; Robinson, SD; Joffre, C; Garrido-Urbani, S; Rodriguez-Manzaneque, JC; Martino-Echarri, E; Aurrand-Lions, M; Sheer, D; Dagna-Bricarelli, F; Nizetic, D; McCabe, CJ; Turnell, AS; Kermorgant, S; Imhof, BA; Adams, R; Fisher, EMC; Tybulewicz, VLJ; Hart, IR and Hodivala-Dilke, KM (2010)
  Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.
  Nature 465, 813-817 PubMed abstract
• Wiseman, FK; Sheppard, O; Linehan, JM; Brandner, S; Tybulewicz, VLJ and Fisher, EMC (2010)
  Generation of a panel of antibodies against proteins encoded on human chromosome 21.
  Journal of Negative Results in Biomedicine 9, 7 PubMed abstract
• Corbetta, S; Gualdoni, S; Ciceri, G; Monari, M; Zuccaro, E; Tybulewicz, VLJ and de Curtis, I (2009)
  Essential role of Rac1 and Rac3 GTPases in neuronal development.
  FASEB Journal 23, 1347-1357 PubMed abstract
• D'Amico, G; Jones, DT; Nye, E; Sapienza, K; Ramjuan, AR; Reynolds, LE; Robinson, SD; Kostourou, V; Martinez, D; Aubyn, D; Grose, R; Thomas, GJ; Spencer-Dene, B; Zicha, D; Davies, D; Tybulewicz, V and Hodivala-Dilke, KM (2009)
  Regulation of lymphatic-blood vessel separation by endothelial Rac1.
  Development 136, 4043-4053 PubMed abstract
• Dumont, C; Corsoni-Tadrzak, A; Ruf, S; de Boer, J; Williams, A; Turner, M; Kioussis, D and Tybulewicz, VL (2009)
  Rac GTPases play critical roles in early T cell development.
  Blood 113, 3990-3998 PubMed abstract
• Fisher, EMC; Lana-Elola, E; Watson, SD; Vassiliou, G and Tybulewicz, VLJ (2009)
  New approaches for modelling sporadic genetic disease in the mouse.
  Disease Models & Mechanisms 2, 446-453 PubMed abstract
• Galante, M; Jani, H; Vanes, L; Daniel, H; Fisher, EMC; Tybulewicz, VLJ; Bliss, TVP and Morice, E (2009)
  Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome.
  Human Molecular Genetics 18, 1449-1463 PubMed abstract
• Gross, O; Poeck, H; Bscheider, M; Dostert, C; Hannesschläger, N; Endres, S; Hartmann, G; Tardivel, A; Schweighoffer, E; Tybulewicz, V; Mocsai, A; Tschopp, J and Ruland, J (2009)
  Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
  Nature 459, 433-U149 PubMed abstract
• Robinson, MJ; Osorio, F; Rosas, M; Freitas, RP; Schweighoffer, E; Groß, O; Verbeek, JS; Ruland, J; Tybulewicz, V; Brown, GD; Moita, LF; Taylor, PR and Reis e Sousa, C (2009)
  Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
  Journal of Experimental Medicine 206, 2037-2051 PubMed abstract
• Saveliev, A and Tybulewicz, VLJ (2009)
  Lymphocyte signaling: beyond knockouts.
  Nature Immunology 10, 361-364 PubMed abstract
• Saveliev, A; Vanes, L; Ksionda, O; Rapley, J; Smerdon, SJ; Rittinger, K and Tybulewicz, VLJ (2009)
  Function of the nucleotide exchange activity of Vav1 in T cell development and activation.
  Science Signaling 2, ra83 PubMed abstract
• Sriskantharajah, S; Belich, MP; Papoutsopoulou, S; Janzen, J; Tybulewicz, V; Seddon, B and Ley, SC (2009)
  Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation.
  Nature Immunology 10, 38-47 PubMed abstract
• Tybulewicz, VLJ and Henderson, RB (2009)
  Rho family GTPases and their regulators in lymphocytes.
  Nature Reviews Immunology 9, 630-644 PubMed abstract
• Wiseman, FK; Alford, KA; Tybulewicz, VLJ and Fisher, EMC (2009)
  Down syndrome--recent progress and future prospects.
  Human Molecular Genetics 18, R75-83 PubMed abstract
• Arana, E; Vehlow, A; Harwood, NE; Vigorito, E; Henderson, R; Turner, M; Tybulewicz, VLJ and Batista, FD (2008)
  Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
  Immunity 28, 88-99 PubMed abstract
• Canzonetta, C; Mulligan, C; Deutsch, S; Ruf, S; O'Doherty, A; Lyle, R; Borel, C; Lin-Marq, N; Delom, F; Groet, J; Schnappauf, F; De Vita, S; Averill, S; Priestley, JV; Martin, JE; Shipley, J; Denyer, G; Epstein, CJ; Fillat, C; Estivill, X; Tybulewicz, VLJ; Fisher, EM; Antonarakis, SE and Nizetic, D (2008)
  DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in down syndrome.
  American Journal of Human Genetics 83, 388-400 PubMed abstract
• David, R; Ma, L; Ivetic, A; Takesono, A; Ridley, AJ; Chai, J-G; Tybulewicz, VL and Marelli-Berg, FM (2008)
  T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
  Blood 113, 3696-3705 PubMed abstract
• Dennehy, KM; Ferwerda, G; Faro-Trindade, I; Pyz, E; Willment, JA; Taylor, PR; Kerrigan, A; Tsoni, SV; Gordon, S; Meyer-Wentrup, F; Adema, GJ; Kullberg, B-J; Schweighoffer, E; Tybulewicz, V; Mora-Montes, HM; Gow, NAR; Williams, DL; Netea, MG and Brown, GD (2008)
  Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
  European Journal of Immunology 38, 500-506 PubMed abstract
• Depoil, D; Fleire, S; Treanor, BL; Weber, M; Harwood, NE; Marchbank, KL; Tybulewicz, VLJ and Batista, FD (2008)
  CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.
  Nature Immunology 9, 63-72 PubMed abstract
• Dumont, C; Henderson, R and Tybulewicz, VLJ (2008)
  Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.
  Methods in Enzymology 439, 235-254 PubMed abstract
• Fallah-Arani, F; Schweighoffer, E; Vanes, L and Tybulewicz, VLJ (2008)
  Redundant role for Zap70 in B cell development and activation.
  European Journal of Immunology 38, 1721-1733 PubMed abstract
• Liang, B; Workman, C; Lee, J; Chew, C; Dale, BM; Colonna, L; Flores, M; Li, N; Schweighoffer, E; Greenberg, S; Tybulewicz, V; Vignali, D and Clynes, R (2008)
  Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.
  Journal of Immunology 180, 5916-5926 PubMed abstract
• Morice, E; Andreae, LC; Cooke, SF; Vanes, L; Fisher, EMC; Tybulewicz, VLJ and Bliss, TVP (2008)
  Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.
  Learning & Memory 15, 492-500 PubMed abstract
• Rapley, J; Tybulewicz, VLJ and Rittinger, K (2008)
  Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.
  EMBO Reports 9, 655-661 PubMed abstract
• Wang, Y; Mulligan, C; Denyer, G; Delom, F; Dagna-Bricarelli, F; Tybulewicz, VLJ; Fisher, EMC; Griffiths, WJ; Nizetic, D and Groet, J (2008)
  Quantitative proteomic characterisation of a mouse embryonic stem cell model of Down syndrome.
  Molecular & Cellular Proteomics 8, 585-595 PubMed abstract
• Wilson, MD; Barbosa-Morais, NL; Schmidt, D; Conboy, CM; Vanes, L; Tybulewicz, VLJ; Fisher, EMC; Tavaré, S and Odom, DT (2008)
  Species-specific transcription in mice carrying human chromosome 21.
  Science 322, 434-438 PubMed abstract
• Yamanishi, Y; Kitaura, J; Izawa, K; Matsuoka, T; Oki, T; Lu, Y; Shibata, F; Yamazaki, S; Kumagai, H; Nakajima, H; Maeda-Yamamoto, M; Tybulewicz, VLJ; Takai, T and Kitamura, T (2008)
  Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
  Blood 11, 688-698 PubMed abstract
• Hughan, SC; Hughes, CE; McCarty, OJT; Schweighoffer, E; Soultanova, I; Ware, J; Tybulewicz, VLJ and Watson, SP (2007)
  GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
  Arteriosclerosis, Thrombosis, and Vascular Biology 27, 422-429 PubMed abstract
• Izawa, K; Kitaura, J; Yamanishi, Y; Matsuoka, T; Oki, T; Shibata, F; Kumagai, H; Nakajima, H; Maeda-Yamamoto, M; Hauchins, JP; Tybulewicz, VLJ; Takai, T and Kitamura, T (2007)
  Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3.
  Journal of Biological Chemistry 282, 17997-18008 PubMed abstract
• Kissil, JL; Walmsley, MJ; Hanlon, L; Haigis, KM; Kim, CFB; Sweet-Cordero, A; Eckman, MS; Tuveson, DA; Capobianco, AJ; Tybulewicz, VLJ and Jacks, T (2007)
  Requirement for Rac1 in a K-ras-induced lung cancer in the mouse.
  Cancer Research 67, 8089-8094 PubMed abstract
• LeibundGut-Landmann, S; Gross, O; Robinson, MJ; Osorio, F; Slack, EC; Tsoni, SV; Schweighoffer, E; Tybulewicz, V; Brown, GD; Ruland, J and Sousa, CRe (2007)
  Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
  Nature Immunology 8, 630-638 PubMed abstract
• Mensah, A; Mulligan, C; Linehan, J; Ruf, S; O'Doherty, A; Grygalewicz, B; Shipley, J; Groet, J; Tybulewicz, V; Fisher, E; Brandner, S and Nizetic, D (2007)
  An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.
  BMC Developmental Biology 7, 131 PubMed abstract
• Nodari, A; Zambroni, D; Quattrini, A; Court, FA; D'Urso, A; Recchia, A; Tybulewicz, VLJ; Wrabetz, L and Feltri, ML (2007)
  β1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination.
  Journal of Cell Biology 177, 1063-1075 PubMed abstract
• Ramaswamy, M; Dumont, C; Cruz, AC; Muppidi, JR; Gomez, TS; Billadeau, DD; Tybulewicz, VLJ and Siegel, RM (2007)
  Cutting Edge: Rac GTPases sensitize activated T cells to die via Fas.
  Journal of Immunology 179, 6384-6388 PubMed abstract
• Schymeinsky, J; Then, C; Sindrilaru, A; Gerstl, R; Jakus, Z; Tybulewicz, VLJ; Scharffetter-Kochanek, K and Walzog, B (2007)
  Syk-mediated translocation of PI3Kδ to the leading edge controls lamellipodium formation and migration of leukocytes.
  PLoS ONE 2, e1132 PubMed abstract
• Slack, EC; Robinson, MJ; Hernanz-Falcón, P; Brown, GD; Williams, DL; Schweighoffer, E; Tybulewicz, VL and Reis, eSC (2007)
  Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan.
  European Journal of Immunology 37, 1600-1612 PubMed abstract
• Zou, W; Kitaura, H; Reeve, J; Long, F; Tybulewicz, VLJ; Shattil, SJ; Ginsberg, MH; Ross, FP and Teitelbaum, SL (2007)
  Syk, c-Src, the αvβ3 integrin and ITAM immuoreceptors, in concert, regulate osteoclastic bone resorption.
  Journal of Cell Biology 176, 877-888 PubMed abstract
• Papoutsopoulou, S; Symons, A; Tharmalingham, T; Belich, MP; Kaiser, F; Kioussis, D; O'Garra, A; Tybulewicz, V and Ley, SC (2006)
  ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
  Nature Immunology 7, 606-615 PubMed abstract
• Robin, C; Ottersbach, K; Durand, C; Peeters, M; Vanes, L; Tybulewicz, V and Dzierzak, E (2006)
  An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells.
  Developmental Cell 11, 171-180 PubMed abstract
• Sebzda, E; Hibbard, C; Sweeney, S; Abtahian, F; Bezman, N; Clemens, G; Maltzman, JS; Cheng, L; Liu, F; Turner, M; Tybulewicz, V; Koretzky, GA and Kahn, ML (2006)
  Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.
  Developmental Cell 11, 349-361 PubMed abstract
• Suzuki-Inoue, K; Fuller, GLJ; García, A; Eble, JA; Pöhlmann, S; Inoue, O; Gartner, TK; Hughan, SC; Pearce, AC; Laing, GD; Theakston, RDG; Schweighoffer, E; Zitzmann, N; Morita, T; Tybulewicz, VLJ; Ozaki, Y and Watson, SP (2006)
  A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
  Blood 107, 542-549 PubMed abstract
• Tybulewicz, VLJ and Fisher, EMC (2006)
  New techniques to understand chromosome dosage: mouse models of aneuploidy.
  Human Molecular Genetics 15, R103-109 PubMed abstract
• Wheeler, AP; Wells, CM; Smith, SD; Vega, FM; Henderson, RB; Tybulewicz, VL and Ridley, AJ (2006)
  Rac1 and Rac2 regulate macrophage morphology but are not essential for migration.
  Journal of Cell Science 119, 2749-2757 PubMed abstract

[Page last updated 1 May 2012]