MRC National Institute for Medical Research, London

Victor Tybulewicz Publications

• Ahmed, MM; Dhanasekaran, AR; Tong, S; Wiseman, FK; Fisher, EMC; Tybulewicz, VLJ and Gardiner, KJ (2013)
  Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.
  Human Molecular Genetics 22, 1709-1724 PubMed abstract
• Gribble, SM; Wiseman, FK; Clayton, S; Prigmore, E; Langley, E; Yang, F; Maguire, S; Fu, B; Rajan, D; Sheppard, O; Scott, C; Hauser, H; Stephens, PJ; Stebbings, LA; Ng, BL; Fitzgerald, T; Quail, MA; Banerjee, R; Rothkamm, K; Tybulewicz, VLJ; Fisher, EMC and Carter, NP (2013)
  Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.
  PLOS ONE 8, e60482 PubMed abstract
• Schweighoffer, E; Vanes, L; Nys, J; Cantrell, D; McCleary, S; Smithers, N and Tybulewicz, Victor LJ (2013)
  The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
  Immunity [Epub ahead of print] PubMed abstract
• Devoy, A; Bunton-Stasyshyn, RKA; Tybulewicz, VLJ; Smith, AJH and Fisher, EMC (2012)
  Genomically humanized mice: technologies and promises.
  Nature Reviews Genetics 13, 14-20 PubMed abstract
• Finney, BA; Schweighoffer, E; Navarro-Núñez, L; Bénézech, C; Barone, F; Hughes, CE; Langan, SA; Lowe, KL; Pollitt, AY; Mourao-Sa, D; Sheardown, S; Nash, GB; Smithers, N; Reis e Sousa, C; Tybulewicz, VLJ and Watson, SP (2012)
  CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
  Blood 119, 1747-1756 PubMed abstract
• Grizenkova, J; Akhtar, S; Hummerich, H; Tomlinson, A; Asante, EA; Wenborn, A; Fizet, J; Poulter, M; Wiseman, FK; Fisher, EMC; Tybulewicz, VLJ; Brandner, S; Collinge, J and Lloyd, SE (2012)
  Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
  Proceedings of the National Academy of Sciences of the United States of America 109, 13722-13727 PubMed abstract
• Haubert, D; Li, J; Saveliev, A; Calzascia, T; Sutter, E; Metzler, B; Kaiser, D; Tybulewicz, VLJ and Weckbecker, G (2012)
  Vav1 GEF activity is required for T cell mediated allograft rejection.
  Transplant Immunology 26, 212-219 PubMed abstract
• Ksionda, O; Saveliev, A; Kochl, R; Rapley, J; Faroudi, M; Smith-Garvin, JE; Wulfing, C; Rittinger, K; Carter, T and Tybulewicz, VLJ (2012)
  Mechanism and function of Vav1 localization in TCR signaling.
  Journal of Cell Science 125, 5302-5314 PubMed abstract
• Sheppard, O; Plattner, F; Rubin, A; Slender, A; Linehan, JM; Brandner, S; Tybulewicz, VLJ; Fisher, EMC and Wiseman, FK (2012)
  Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
  Neurobiology of Aging 33, 828.e831- 828.e844 PubMed abstract
• Sheppard, O; Wiseman, FK; Ruparelia, A; Tybulewicz, VLJ and Fisher, EMC (2012)
  Mouse models of aneuploidy.
  Scientific World Journal 2012, 214078 PubMed abstract
• Vidaki, M; Tivodar, S; Doulgeraki, K; Tybulewicz, V; Kessaris, N; Pachnis, V and Karagogeos, D (2012)
  Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex.
  Cerebral Cortex 22, 680-692 PubMed abstract
• Cleary, JO; Wiseman, FK; Norris, FC; Price, AN; Choy, M; Tybulewicz, VLJ; Ordidge, RJ; Brandner, S; Fisher, EMC and Lythgoe, MF (2011)
  Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.
  Neuroimage 56, 974-983 PubMed abstract
• da Gloria Sousa, M; Reid, DM; Schweighoffer, E; Tybulewicz, V; Ruland, J; Langhorne, J; Yamasaki, S; Taylor, PR; Almeida, SR and Brown, GD (2011)
  Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
  Cell Host & Microbe 9, 436-443 PubMed abstract
• Duchon, A; Pothion, S; Brault, V; Sharp, AJ; Tybulewicz, VLJ; Fisher, EMC and Herault, Y (2011)
  The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.
  Behavioural Brain Research 217, 271-281 PubMed abstract
• Lana-Elola, E; Watson-Scales, SD; Fisher, EMC and Tybulewicz, VLJ (2011)
  Down syndrome: searching for the genetic culprits.
  Disease Models & Mechanisms 4, 586-595
• Singleton, KL; Gosh, M; Dandekar, RD; Au-Yeung, BB; Ksionda, O; Tybulewicz, VLJ; Altman, A; Fowell, DJ and Wülfing, C (2011)
  Itk controls the spatiotemporal organization of T cell activation.
  Science Signaling 4, ra66 PubMed abstract
• Alford, K; Slender, A; Vanes, L; Li, Z; Fisher, EMC; Nizetic, D; Orkin, SH; Roberts, I and Tybulewicz, VLJ (2010)
  Perturbed hematopoiesis in the Tc1 mouse model of Down Syndrome.
  Blood 115, 2928-2937 PubMed abstract
• Anderson, KE; Chessa, TAM; Davidson, K; Henderson, RB; Walker, S; Tolmachova, T; Grys, K; Rausch, O; Seabra, M; Tybulewicz, VLJ; Stephens, LR and Hawkins, PT (2010)
  PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.
  Blood 116, 4978-4989 PubMed abstract
• D'Amico, G; Robinson, SD; Germain, M; Reynolds, LE; Thomas, GJ; Elia, G; Saunders, G; Fruttiger, M; Tybulewicz, V; Mavria, G and Hodivala-Dilke, KM (2010)
  Endothelial-Rac1 is not required for tumor angiogenesis unless αvβ3-integrin is absent.
  PLOS ONE 5, e9766 PubMed abstract
• De Vita, S; Canzonetta, C; Mulligan, C; Delom, F; Groet, J; Baldo, C; Vanes, L; Dagna-Bricarelli, F; Hoischen, A; Veltman, J; Fisher, EMC; Tybulewicz, VLJ and Nizetic, D (2010)
  Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.
  Oncogene 29, 6102-6114 PubMed abstract
• Dunlevy, L; Bennett, M; Slender, A; Lana-Elola, E; Tybulewicz, VL; Fisher, EMC and Mohun, T (2010)
  Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.
  Cardiovascular Research 88, 287-295 PubMed abstract
• Faroudi, M; Hons, M; Zachacz, A; Dumont, C; Lyck, R; Stein, JV and Tybulewicz, VLJ (2010)
  Critical roles for Rac GTPases in T cell migration to and within lymph nodes.
  Blood 116, 5536-5547 PubMed abstract
• Henderson, RB; Grys, K; Vehlow, A; de Bettignies, C; Zachacz, A; Henley, T; Turner, M; Batista, F and Tybulewicz, VLJ (2010)
  A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
  Journal of Experimental Medicine 207, 837-853 PubMed abstract
• Mócsai, A; Ruland, J and Tybulewicz, VLJ (2010)
  The SYK tyrosine kinase: a crucial player in diverse biological functions.
  Nature Reviews Immunology 10, 387-402 PubMed abstract
• Reynolds, LE; Watson, AR; Baker, M; Jones, TA; D'Amico, G; Robinson, SD; Joffre, C; Garrido-Urbani, S; Rodriguez-Manzaneque, JC; Martino-Echarri, E; Aurrand-Lions, M; Sheer, D; Dagna-Bricarelli, F; Nizetic, D; McCabe, CJ; Turnell, AS; Kermorgant, S; Imhof, BA; Adams, R; Fisher, EMC; Tybulewicz, VLJ; Hart, IR and Hodivala-Dilke, KM (2010)
  Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.
  Nature 465, 813-817 PubMed abstract
• Wiseman, FK; Sheppard, O; Linehan, JM; Brandner, S; Tybulewicz, VLJ and Fisher, EMC (2010)
  Generation of a panel of antibodies against proteins encoded on human chromosome 21.
  Journal of Negative Results in Biomedicine 9, 7 PubMed abstract
• Corbetta, S; Gualdoni, S; Ciceri, G; Monari, M; Zuccaro, E; Tybulewicz, VLJ and de Curtis, I (2009)
  Essential role of Rac1 and Rac3 GTPases in neuronal development.
  FASEB Journal 23, 1347-1357 PubMed abstract
• D'Amico, G; Jones, DT; Nye, E; Sapienza, K; Ramjuan, AR; Reynolds, LE; Robinson, SD; Kostourou, V; Martinez, D; Aubyn, D; Grose, R; Thomas, GJ; Spencer-Dene, B; Zicha, D; Davies, D; Tybulewicz, V and Hodivala-Dilke, KM (2009)
  Regulation of lymphatic-blood vessel separation by endothelial Rac1.
  Development 136, 4043-4053 PubMed abstract
• Dumont, C; Corsoni-Tadrzak, A; Ruf, S; de Boer, J; Williams, A; Turner, M; Kioussis, D and Tybulewicz, VL (2009)
  Rac GTPases play critical roles in early T cell development.
  Blood 113, 3990-3998 PubMed abstract
• Fisher, EMC; Lana-Elola, E; Watson, SD; Vassiliou, G and Tybulewicz, VLJ (2009)
  New approaches for modelling sporadic genetic disease in the mouse.
  Disease Models & Mechanisms 2, 446-453 PubMed abstract
• Galante, M; Jani, H; Vanes, L; Daniel, H; Fisher, EMC; Tybulewicz, VLJ; Bliss, TVP and Morice, E (2009)
  Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome.
  Human Molecular Genetics 18, 1449-1463 PubMed abstract
• Gross, O; Poeck, H; Bscheider, M; Dostert, C; Hannesschläger, N; Endres, S; Hartmann, G; Tardivel, A; Schweighoffer, E; Tybulewicz, V; Mocsai, A; Tschopp, J and Ruland, J (2009)
  Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
  Nature 459, 433-U149 PubMed abstract
• Robinson, MJ; Osorio, F; Rosas, M; Freitas, RP; Schweighoffer, E; Groß, O; Verbeek, JS; Ruland, J; Tybulewicz, V; Brown, GD; Moita, LF; Taylor, PR and Reis e Sousa, C (2009)
  Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
  Journal of Experimental Medicine 206, 2037-2051 PubMed abstract
• Saveliev, A and Tybulewicz, VLJ (2009)
  Lymphocyte signaling: beyond knockouts.
  Nature Immunology 10, 361-364 PubMed abstract
• Saveliev, A; Vanes, L; Ksionda, O; Rapley, J; Smerdon, SJ; Rittinger, K and Tybulewicz, VLJ (2009)
  Function of the nucleotide exchange activity of Vav1 in T cell development and activation.
  Science Signaling 2, ra83 PubMed abstract
• Sriskantharajah, S; Belich, MP; Papoutsopoulou, S; Janzen, J; Tybulewicz, V; Seddon, B and Ley, SC (2009)
  Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation.
  Nature Immunology 10, 38-47 PubMed abstract
• Tybulewicz, VLJ and Henderson, RB (2009)
  Rho family GTPases and their regulators in lymphocytes.
  Nature Reviews Immunology 9, 630-644 PubMed abstract
• Wiseman, FK; Alford, KA; Tybulewicz, VLJ and Fisher, EMC (2009)
  Down syndrome--recent progress and future prospects.
  Human Molecular Genetics 18, R75-83 PubMed abstract
• Arana, E; Vehlow, A; Harwood, NE; Vigorito, E; Henderson, R; Turner, M; Tybulewicz, VLJ and Batista, FD (2008)
  Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
  Immunity 28, 88-99 PubMed abstract
• Canzonetta, C; Mulligan, C; Deutsch, S; Ruf, S; O'Doherty, A; Lyle, R; Borel, C; Lin-Marq, N; Delom, F; Groet, J; Schnappauf, F; De Vita, S; Averill, S; Priestley, JV; Martin, JE; Shipley, J; Denyer, G; Epstein, CJ; Fillat, C; Estivill, X; Tybulewicz, VLJ; Fisher, EM; Antonarakis, SE and Nizetic, D (2008)
  DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in down syndrome.
  American Journal of Human Genetics 83, 388-400 PubMed abstract
• David, R; Ma, L; Ivetic, A; Takesono, A; Ridley, AJ; Chai, J-G; Tybulewicz, VL and Marelli-Berg, FM (2008)
  T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
  Blood 113, 3696-3705 PubMed abstract
• Dennehy, KM; Ferwerda, G; Faro-Trindade, I; Pyz, E; Willment, JA; Taylor, PR; Kerrigan, A; Tsoni, SV; Gordon, S; Meyer-Wentrup, F; Adema, GJ; Kullberg, B-J; Schweighoffer, E; Tybulewicz, V; Mora-Montes, HM; Gow, NAR; Williams, DL; Netea, MG and Brown, GD (2008)
  Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
  European Journal of Immunology 38, 500-506 PubMed abstract
• Depoil, D; Fleire, S; Treanor, BL; Weber, M; Harwood, NE; Marchbank, KL; Tybulewicz, VLJ and Batista, FD (2008)
  CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.
  Nature Immunology 9, 63-72 PubMed abstract
• Dumont, C; Henderson, R and Tybulewicz, VLJ (2008)
  Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.
  Methods in Enzymology 439, 235-254 PubMed abstract
• Fallah-Arani, F; Schweighoffer, E; Vanes, L and Tybulewicz, VLJ (2008)
  Redundant role for Zap70 in B cell development and activation.
  European Journal of Immunology 38, 1721-1733 PubMed abstract
• Liang, B; Workman, C; Lee, J; Chew, C; Dale, BM; Colonna, L; Flores, M; Li, N; Schweighoffer, E; Greenberg, S; Tybulewicz, V; Vignali, D and Clynes, R (2008)
  Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.
  Journal of Immunology 180, 5916-5926 PubMed abstract
• Morice, E; Andreae, LC; Cooke, SF; Vanes, L; Fisher, EMC; Tybulewicz, VLJ and Bliss, TVP (2008)
  Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.
  Learning & Memory 15, 492-500 PubMed abstract
• Rapley, J; Tybulewicz, VLJ and Rittinger, K (2008)
  Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.
  EMBO Reports 9, 655-661 PubMed abstract
• Wang, Y; Mulligan, C; Denyer, G; Delom, F; Dagna-Bricarelli, F; Tybulewicz, VLJ; Fisher, EMC; Griffiths, WJ; Nizetic, D and Groet, J (2008)
  Quantitative proteomic characterisation of a mouse embryonic stem cell model of Down syndrome.
  Molecular & Cellular Proteomics 8, 585-595 PubMed abstract
• Wilson, MD; Barbosa-Morais, NL; Schmidt, D; Conboy, CM; Vanes, L; Tybulewicz, VLJ; Fisher, EMC; Tavaré, S and Odom, DT (2008)
  Species-specific transcription in mice carrying human chromosome 21.
  Science 322, 434-438 PubMed abstract
• Yamanishi, Y; Kitaura, J; Izawa, K; Matsuoka, T; Oki, T; Lu, Y; Shibata, F; Yamazaki, S; Kumagai, H; Nakajima, H; Maeda-Yamamoto, M; Tybulewicz, VLJ; Takai, T and Kitamura, T (2008)
  Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
  Blood 11, 688-698 PubMed abstract

[Page last updated 1 May 2013]