MRC National Institute for Medical Research, London

Tony Holder Publications

• Biswas, S; Spencer, AJ; Forbes, EK; Gilbert, SC; Holder, AA; Hill, AVS and Draper, SJ (2013)
  Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection.
  Journal of Immunology 188, 5041-5053 PubMed abstract
• Chapman, TM; Osborne, SA; Bouloc, N; Large, JM; Wallace, C; Birchall, K; Ansell, KH; Jones, HM; Taylor, D; Clough, B; Green, JL and Holder, AA (2013)
  Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
  Bioorganic & Medicinal Chemistry Letters [Epub ahead of print] PubMed abstract
• Faber, BW; Younis, S; Remarque, EJ; Rodriguez Garcia, R; Riasat, V; Walraven, V; van der Werff, N; van der Eijk, M; Cavanagh, DR; Holder, AA; Thomas, AW and Kocken, CHM (2013)
  Diversity covering AMA1-MSP1₁₉ fusion proteins as malaria vaccines.
  Infection and Immunity 81, 1479-1490
• Patzewitz, E-M; Guttery, DS; Poulin, B; Ramakrishnan, C; Ferguson, DJP; Wall, RJ; Brady, D; Holder, AA; Szöőr, B and Tewari, R (2013)
  An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission.
  Cell Reports 3, [Epub ahead of print] PubMed abstract
• Rackham, MD; Brannigan, JA; Moss, DK; Yu, Z; Wilkinson, AJ; Holder, AA; Tate, EW and Leatherbarrow, RJ (2013)
  Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferase.
  Journal of Medicinal Chemistry 546, 371-375 PubMed abstract
• Sato, S; Sesay, AK and Holder, AA (2013)
  The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi.
  PLOS ONE 8, e61778 PubMed abstract
• Guttery, DS; Holder, AA and Tewari, R (2012 )
  Sexual development in Plasmodium: lessons from functional analyses.
  PLOS Pathogens 8, e1002404 PubMed abstract
• Amambua-Ngwa, A; Tetteh, KKA; Manske, M; Gomez-Escobar, N; Stewart, LB; Deerhake, ME; Cheeseman, IH; Newbold, CI; Holder, AA; Knuepfer, E; Janha, O; Jallow, M; Campino, S; Macinnis, B; Kwiatkowski, DP and Conway, DJ (2012)
  Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.
  PLOS Genetics 8, e1002992 PubMed abstract
• Bell, AS; Mills, JE; Williams, GP; Brannigan, JA; Wilkinson, AJ; Parkinson, T; Leatherbarrow, RJ; Tate, EW; Holder, AA and Smith, DF (2012)
  Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
  PLoS Neglected Tropical Diseases 6, e1625 PubMed abstract
• Cruz, LN; Juliano, MA; Budu, A; Juliano, L; Holder, AA; Blackman, MJ and Garcia, CRS (2012)
  Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
  Malaria Journal 11, 69 PubMed abstract
• da Cruz, LN; Juliano, MA; Budu, A; Juliano, L; Holder, AA; Blackman, MJ and Garcia, CRS (2012)
  Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
  Malaria Journal 11, PubMed abstract
• Douse, CH; Green, JL; Salgado, PS; Simpson, PJ; Thomas, JC; Langsley, G; Holder, AA; Tate, EW and Cota, E (2012)
  Regulation of the Plasmodium motor complex: phosphorylation of Myosin A Tail Interacting Protein (MTIP) loosens its grip on MyoA.
  Journal of Biological Chemistry 287, 36968-36977 PubMed abstract
• Farrow, RE; Green, J; Katismitsoulia, Z; Taylor, WR; Holder, AA and Molloy, JE (2012)
  The mechanism of erythrocyte invasion by the malarial parasite, Plasmodium falciparum.
  Seminars in Cell & Developmental Biology 22, 953-960 PubMed abstract
• Goncalves, V; Brannigan, JA; Whalley, D; Ansell, KH; Saxty, B; Holder, AA; Wilkinson, AJ; Tate, EW and Leatherbarrow, RJ (2012)
  Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
  Journal of Medicinal Chemistry 55, 3578-3582 PubMed abstract
• Guttery, DS; Ferguson, DJP; Poulin, B; Xu, Z; Straschil, U; Klop, O; Solyakov, L; Sandrini, SM; Brady, D; Nieduszynski, CA; Janse, CJ; Holder, AA; Tobin, AB and Tewari, R (2012)
  A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.
  PLOS Pathogens 8, e1002554 PubMed abstract
• Guttery, DS; Poulin, B; Ferguson, DJP; Szoor, B; Wickstead, B; Carroll, PL; Ramakrishnan, C; Brady, D; Patzewitz, E-M; Straschil, U; Solyakov, L; Green, JL; Sinden, RE; Tobin, AB; Holder, AA and Tewari, R (2012)
  A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.
  PLOS Pathogens 8, e1002948 PubMed abstract
• Holder, AA; Mohd Ridzuan, MA and Green, JL (2012)
  Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite.
  Microbes and Infection 14, 825-830 PubMed abstract
• Lasonder, E; Green, JL; Camarda, G; Talabani, H; Holder, AA; Langsley, G and Alano, P (2012)
  The Plasmodium falciparum schizont phospho-proteome reveals extensive phosphatidylinositol and cAMP-Protein Kinase A signalling.
  Journal of Proteome Research 11, 5323-5337 PubMed abstract
• Moon, RW; Hall, J; Rangkuti, F; Ho, YS; Almond, N; Mitchell, GH; Pain, A; Holder, AA and Blackman, MJ (2012)
  Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.
  Proceedings of the National Academy of Sciences 110, 531-536
• Moss, DK; Remarque, EJ; Faber, BW; Cavanagh, DR; Arnot, DE; Thomas, AW and Holder, AA (2012)
  Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion and intracellular parasite development.
  Infection and Immunity 80, 1280-1287 PubMed abstract
• Ridzuan, MAM; Moon, RW; Knuepfer, E; Black, S; Holder, AA and Green, JL (2012)
  Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development.
  PLOS ONE 7, e33845 PubMed abstract
• Yu, Z; Brannigan, JA; Moss, DK; Brzozowski, AM; Wilkinson, AJ; Holder, AA; Tate, EW and Leatherbarrow, RJ (2012)
  Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for anti-malarial drug discovery.
  Journal of Medicinal Chemistry 55, 8879-8890 PubMed abstract
• Bisseye, C; Yindom, LM; Simpore, J; Morgan, WD; Holder, AA and Ismaili, J (2011)
  An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria.
  Clinical and Experimental Immunology 166, 366-373 PubMed abstract
• Biswas, S; Dicks, MDJ; Long, CA; Remarque, EJ; Siani, L; Colloca, S; Cottingham, MG; Holder, AA; Gilbert, SC; Hill, AVS and Draper, SJ (2011)
  Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.
  PLOS ONE 6, e20977 PubMed abstract
• Gómez, ND; Safeukui, I; Adelani, AA; Tewari, R; Reddy, JK; Rao, S; Holder, A; Buffet, P; Mohandas, N and Haldar, K (2011)
  Deletion of a malaria invasion gene reduces death and anemia, in model hosts.
  PLOS ONE 6, e25477 PubMed abstract
• Ogun, SA; Tewari, R; Otto, TD; Howell, SA; Knuepfer, E; Cunningham, DA; Xu, Z; Pain, A and Holder, AA (2011)
  Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein.
  PLOS Pathogens 7, e1001288 PubMed abstract
• Shi, J; McIntosh, RS; Adame-Gallegos, J; Dehal, PK; van Egmond, M; van de Winkel, J; Draper, SJ; Forbes, EK; Corran, PH; Holder, AA; Woof, JM and Pleass, RJ (2011)
  The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1₁₉).
  BMC Biotechnology 11, 1-8 PubMed abstract
• Thøgersen, RL; Holder, AA; Hill, AVS; Arnot, DE; Imoukhuede, EB and Leroy, O (2011)
  Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?
  Malaria Journal 10, 255 PubMed abstract
• Cook, WJ; Smith, CD; Senkovich, O; Holder, AA and Chattopadhyay, D (2010)
  Structure of Plasmodium falciparum ADP-ribosylation factor 1.
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 66, 1426-1431 PubMed abstract
• Eslava, I; Payares, G; Pernia, BM; Holder, AA and Spencer, LM (2010)
  Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii.
  Malaria Journal 9, PubMed abstract
• Goodman, AL; Epp, C; Moss, D; Holder, AA; Wilson, JM; Gao, GP; Long, CA; Remarque, EJ; Thomas, AW; Ammendola, V; Colloca, S; Dicks, MDJ; Biswas, S; Seibel, D; van Duivenvoorde, LM; Gilbert, SC; Hill, AVS and Draper, SJ (2010)
  New candidate vaccines against blood-stage P. falciparum malaria: Prime-boost immunization regimes incorporating human and simian adenoviral vectors and poxviral vectors expressing an optimized antigen based on merozoite surface protein 1.
  Infection and Immunity 78, 4601-4612 PubMed abstract
• Kadekoppala, M and Holder, AA (2010)
  Merozoite surface proteins of the malaria parasite: the MSP1 complex and the MSP7 family.
  International Journal for Parasitology 40, 1155-1161 PubMed abstract
• Kadekoppala, M; Ogun, SA; Howell, S; Gunaratne, RS and Holder, AA (2010)
  Systematic genetic analysis of the Plasmodium falciparum MSP7-like family reveals differences in protein expression, location and importance in asexual growth of the blood stage parasite.
  Eukaryotic Cell 9, 1064-1074 PubMed abstract
• Ngoundou-Landji, J; Nwuba, RI; Anumudu, CI; Odaibo, AB; Matondo Maya, WD; Awobode, HO; Okafor, CM; Morenikeji, OA; Asinobi, A; Nwagwu, M; Holder, AA and Ntoumi, F (2010)
  Fine specificity of anti-MSP1₁₉ antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection.
  Malaria Journal 9, 287 PubMed abstract
• Omosun, YO; Adoro, S; Anumudu, CI; Odaibo, A; Holder, AA; Nwagwu, M and Nwuba, RI (2010)
  Total immunoglobulin G and IgG1 subclass levels specific for the MSP-119 of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodies.
  African Health Sciences 10, 106-110
• Schmitz, S; Schaap, IAT; Kleinjung, J; Harder, S; Grainger, M; Calder, L; Rosenthal, PB; Holder, AA and Veigel, C (2010)
  Malaria parasite actin polymerisation and filament structure.
  Journal of Biological Chemistry 285, 36577-36585 PubMed abstract
• Straschil, U; Talman, AM; Ferguson, DJP; Bunting, KA; Xu, Z; Bailes, E; Sinden, RE; Holder, AA; Smith, EF; Coates, JC and Tewari, R (2010)
  The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes.
  PLOS ONE 5, e12901 PubMed abstract
• Taylor, HM; McRobert, L; Grainger, M; Sicard, A; Dluzewski, AR; Hopp, CS; Holder, AA and Baker, DA (2010)
  The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood stage schizogony.
  Eukaryotic Cell 9, 37-45 PubMed abstract
• Thomas, JC; Green, JL; Howson, RI; Simpson, P; Moss, DK; Martin, SR; Holder, AA; Cota, E and Tate, EW (2010)
  Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
  Molecular BioSystems 6, 494-498 PubMed abstract
• Bisseye, C; van der Sande, M; Morgan, WD; Holder, AA; Pinder, M and Ismaili, J (2009)
  Plasmodium falciparum infection of the placenta impacts on the T helper type 1 (Th1)/Th2 balance of neonatal T cells through CD4⁺CD25⁺ forkhead box P3⁺ regulatory T cells and interleukin-10.
  Clinical and Experimental Immunology 158, 287-293 PubMed abstract
• Blythe, JE; Niang, M; Marsh, K; Holder, AA; Langhorne, J and Preiser, PR (2009)
  Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates.
  Malaria Journal 8, 140 PubMed abstract
• Craig, AG; Holder, AA; Leroy, OY and Ventura, RA (2009)
  Malaria vaccines - how and when to proceed?
  Trends in Parasitology 25, 535-537 PubMed abstract
• Doerig, C; Baker, D; Billker, O; Blackman, MJ; Chitnis, C; Kumar, DS; Heussler, V; Holder, AA; Kocken, C; Krishna, S; Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U and Alano, P (2009)
  Signalling in malaria parasites.
  Parasite 16, 169-182 PubMed abstract
• Hinds, L; Green, JL; Knuepfer, E; Grainger, M and Holder, AA (2009)
  A novel putative GPI-anchored micronemal antigen of Plasmodium falciparum that binds to erythrocytes.
  Eukaryotic Cell 8, 1869-1879 PubMed abstract
• Holder, AA (2009)
  The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malaria.
  Parasitology 136, 1445-1456 PubMed abstract
• Holder, AA (2009)
  Malaria vaccines: where next?
  PLOS Pathogens 5, e1000638 PubMed abstract
• Holder, AA and Veigel, C (2009)
  Formin' an invasion machine: actin polymerization in invading apicomplexans.
  Trends in Parasitology 25, 1-3 PubMed abstract
• Lazarou, M; Guevara Patiño, JA; Jennings, RM; McIntosh, RS; Shi, J; Howell, S; Cullen, E; Jones, T; Adame-Gallegos, JR; Chappel, JA; McBride, JS; Blackman, MJ; Holder, AA and Pleass, RJ (2009)
  Inhibition of erythrocyte invasion and Plasmodium falciparum Merozoite Surface Protein 1 processing by human IgG1 and IgG3 antibodies.
  Infection and Immunity 77, 5659-5667 PubMed abstract
• Okafor, CMF; Anumudu, CI; Omosun, YO; Uthaipibull, C; Ayede, I; Awobode, HO; Odaibo, AB; Langhorne, J; Holder, AA; Nwuba, RI and Troye-Blomberg, M (2009)
  Cellular responses to modified Plasmodium falciparum MSP1₁₉ antigens in individuals previously exposed to natural malaria infection.
  Malaria Journal 8, 263 PubMed abstract
• Omosun, YO; Adoro, S; Anumudu, CI; Odaibo, AB; Uthiapibull, C; Holder, AA; Nwagwu, M and Nwuba, RI (2009)
  Antibody specificities of children living in a malaria endemic area to inhibitory and blocking epitopes on MSP-1₁₉ of Plasmodium falciparum.
  Acta Tropica 109, 208-212 PubMed abstract
• Arnot, DE; Cavanagh, DR; Remarque, EJ; Creasey, AM; Sowa, MPK; Morgan, WD; Holder, AA; Longacre, S and Thomas, AW (2008)
  Comparative testing of six Plasmodium falciparum merozoite stage antigen-based malaria vaccine candidates.
  Clinical and Vaccine Immunology 15, 1345-1355 PubMed abstract
• Blythe, JE; Yam, XY; Kuss, C; Bozdech, Z; Holder, AA; Marsh, K; Langhorne, J and Preiser, PR (2008)
  Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and locate to the surface membrane of infected red blood cells and the apical tip of merozoites.
  Infection and Immunity 76, 3329-3336 PubMed abstract
• Bowyer, PW; Tate, EW; Leatherbarrow, RJ; Holder, AA; Smith, DF and Brown, KA (2008)
  N-Myristoyltransferase: a prospective drug target for protozoan parasites.
  ChemMedChem 3, 402-408 PubMed abstract
• Dluzewski, AR; Ling, IT; Hopkins, JM; Grainger, M; Margos, G; Mitchell, GH; Holder, AA and Bannister, LH (2008)
  Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1₁₉).
  PLOS ONE 3, e3085 PubMed abstract
• Draper, SJ; Moore, AC; Goodman, AL; Long, CA; Holder, AA; Gilbert, SC; Hill, F and Hill, AVS (2008)
  Effective induction of high-titer antibodies by viral vector vaccines.
  Nature Medicine 14, 819-821 PubMed abstract
• Green, JL; Rees-Channer, RR; Howell, SA; Martin, SR; Knuepfer, E; Taylor, HM; Grainger, M and Holder, AA (2008)
  The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase.
  Journal of Biological Chemistry 283, 30980-30989 PubMed abstract
• Heal, WP; Wickramasinghe, SR; Bowyer, PW; Holder, AA; Smith, DF; Leatherbarrow, RJ and Tate, EW (2008)
  Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.
  Chemical Communications 480-482 PubMed abstract
• Kadekoppala, M; O'Donnell, RA; Grainger, M; Crabb, BS and Holder, AA (2008)
  Deletion of the Plasmodium falciparum Merozoite Surface Protein 7 gene impairs parasite invasion of erythrocytes.
  Eukaryotic Cell 7, 2123-2132 PubMed abstract
• Narum, DL; Nguyen, V; Zhang, Y; Glen, J; Shimp, RL; Lambert, L; Ling, IT; Reiter, K; Ogun, SA; Long, C; Holder, AA and Herrera, R (2008)
  Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection.
  Infection and Immunity 76, 4876-4882 PubMed abstract
• Ogun, SA; Dumon-Seignovert, L; Marchand, J-B; Holder, AA and Hill, F (2008)
  The oligomerization domain of C4-binding protein acts as an adjuvant: a fusion protein of MSP1₁₉ with the murine C4bp domain protects mice against malaria.
  Infection and Immunity 76, 3817-3823 PubMed abstract

[Page last updated 1 May 2013]