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The structure of Nijmegen-breakage syndrome protein 1

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Steve Smerdon Publications

Rock, JM; Lim, D; Stach, L; Ogrodowicz, RW; Keck, JM; Jones, MH; Wong, CCL; Yates, JR; Winey, M; Smerdon, SJ; Yaffe, MB and Amon, A (2013)
Activation of the yeast hippo pathway by phosphorylation-dependent assembly of signaling complexes.
Science [Epub ahead of print] PubMed abstract
Chapman, TM; Bouloc, N; Buxton, RS; Chugh, J; Lougheed, KEA; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL and Whalley, D (2012)
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
Bioorganic & Medicinal Chemistry Letters 22, 3349-3353 PubMed abstract
Jungmichel, S; Clapperton, JA; Lloyd, J; Hari, FJ; Spycher, C; Pavic, L; Li, J; Haire, LF; Bonalli, M; Larsen, DH; Lukas, C; Lukas, J; Macmillan, D; Nielsen, ML; Stucki, M and Smerdon, SJ (2012)
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Nucleic Acids Research 40, 3913-3928 PubMed abstract
Martino, L; Pennell, S; Kelly, G; Bui, TTT; Kotik-Kogan, O; Smerdon, SJ; Drake, AF; Curry, S and Conte, MR (2012)
Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.
Nucleic Acids Research 40, 1381-1394 PubMed abstract
Yata, K; Lloyd, J; Maslen, S; Bleuyard, J-Y; Skehel, M; Smerdon, SJ and Esashi, F (2012)
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Molecular Cell 45, 371-383 PubMed abstract
Alexander, J; Lim, D; Joughin, BA; Hegemann, B; Hutchins, JRA; Ehrenberger, T; Ivins, F; Sessa, F; Hudecz, O; Nigg, EA; Fry, AM; Musacchio, A; Stukenberg, PT; Mechtler, K; Peters, J-M; Smerdon, SJ and Yaffe, MB (2011)
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.
Science Signaling 4, ra42 PubMed abstract
Croasdale, R; Ivins, FJ; Muskett, F; Daviter, T; Scott, DJ; Hardy, T; Smerdon, SJ; Fry, AM and Pfuhl, M (2011)
An undecided coiled coil. The leucine zipper of Nek2 kinase exhibits atypical conformational exchaange dymanics.
Journal of Biological Chemistry 286, 27537-27547 PubMed abstract
Lougheed, KEA; Osborne, SA; Saxty, B; Whalley, D; Chapman, T; Bouloc, N; Chugh, J; Nott, TJ; Patel, D; Spivey, VL; Kettleborough, CA; Bryans, JS; Taylor, DL; Smerdon, SJ and Buxton, RS (2011)
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Tuberculosis 91, 277-286 PubMed abstract
Spivey, VL; Molle, V; Whalan, RH; Rodgers, A; Leiba, J; Stach, L; Walker, KB; Smerdon, SJ and Buxton, RS (2011)
Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.
Journal of Biological Chemistry 286, 26198-26209 PubMed abstract
Becherel, OJ; Jakob, B; Cherry, AL; Gueven, N; Fusser, M; Kijas, AW; Peng, C; Katyal, S; McKinnon, PJ; Chen, J; Epe, B; Smerdon, SJ; Taucher-Scholz, G and Lavin, MF (2010)
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.
Nucleic Acids Research 38, 1489-1503 PubMed abstract
Masania, J; Li, J; Smerdon, SJ and Macmillan, D (2010)
Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer.
Organic & Biomolecular Chemistry 8, 5113-5119 PubMed abstract
Pennell, S; Westcott, S; Ortiz-Lombardía, M; Patel, D; Li, J; Nott, TJ; Mohammed, D; Buxton, RS; Yaffe, MB; Verma, C and Smerdon, SJ (2010)
Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.
Structure 18, 1587-1595 PubMed abstract
Taylor, IA; Goldstone, DC; Pala, P; Haire, LF and Smerdon, SJ (2010)
Structure of the amino-terminal domain from the cell-cycle regulator Swi6.
Proteins 78, 2861-2865 PubMed abstract
van Vugt, MATM; Gardino, AK; Linding, R; Ostheimer, GJ; Reinhardt, HC; Ong, S-E; Tan, CS; Miao, H; Keezer, SM; Li, J; Pawson, T; Lewis, TA; Carr, SA; Smerdon, SJ; Brummelkamp, TR and Yaffe, MB (2010)
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G₂/M DNA damage checkpoint.
PLOS Biology 8, e1000287 PubMed abstract
Lloyd, J; Chapman, JR; Clapperton, JA; Haire, LF; Hartsuiker, E; Li, J; Carr, AM; Jackson, SP and Smerdon, SJ (2009)
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
Cell 139, 100-111 PubMed abstract
Nott, TJ; Kelly, G; Stach, L; Li, J; Westcott, S; Patel, D; Hunt, DM; Howell, S; Buxton, RS; O'Hare, HM and Smerdon, SJ (2009)
An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.
Science Signaling 2, ra12 PubMed abstract
Saveliev, A; Vanes, L; Ksionda, O; Rapley, J; Smerdon, SJ; Rittinger, K and Tybulewicz, VLJ (2009)
Function of the nucleotide exchange activity of Vav1 in T cell development and activation.
Science Signaling 2, ra83 PubMed abstract
Canman, JC; Lewellyn, L; Laband, K; Smerdon, SJ; Desai, A; Bowerman, B and Oegema, K (2008)
Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.
Science 322, 1543-1546 PubMed abstract
Li, J; Taylor, IA; Lloyd, J; Clapperton, JA; Howell, S; Macmillan, D and Smerdon, SJ (2008)
CHK2 oligomerization studied by phosphopeptide ligation: Implications for regulation and phosphodependent interactions.
Journal of Biological Chemistry 283, 36019-36030 PubMed abstract
Pennell, S; Manktelow, E; Flatt, A; Kelly, G; Smerdon, SJ and Brierley, I (2008)
The stimulatory RNA of the Visna-Maedi retrovirus ribosomal frameshifting signal is an unusual pseudoknot with an interstem element.
RNA 14, 1366-1377 PubMed abstract
Pennell, S and Smerdon, SJ (2008)
Pellino proteins splitting up the FHAmily!.
Structure 16, 1752-1754 PubMed abstract
Withers-Martinez, C; Haire, LF; Hackett, F; Walker, PA; Howell, SA; Smerdon, SJ; Dodson, GG and Blackman, MJ (2008)
Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.
Journal of Molecular Biology 375, 773-781 PubMed abstract