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Steve Ley Publications

Gantke, T; Boussouf, S; Janzen, J; Morrice, NA; Howell, S; Mühlberger, E and Ley, SC (2013)
Ebola virus VP35 induces high-level production of recombinant TPL-2 / ABIN-2 / NF-κB1 p105 complex in co-transfected HEK-293 cells.
Biochemical Journal [Epub ahead of print] PubMed abstract
Gantke, T; Sriskantharajah, S; Sadowski, M and Ley, SC (2012)
IκB kinase regulation of the TPL-2/ERK MAPK pathway.
Immunological Reviews 246, 168-182 PubMed abstract
Risco, A; del Fresno, C; Mambol, A; Alsina-Beauchamp, D; MacKenzie, KF; Yang, H-T; Barber, DF; Morcelle, C; Arthur, JSC; Ley, SC; Ardavin, C and Cuenda, A (2012)
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.
Proceedings of the National Academy of Sciences of the United States of America 109, 11200-11205 PubMed abstract
Roget, K; Ben-Addi, A; Mambole-Dema, A; Gantke, T; Yang, H-T; Janzen, J; Morrice, N; Abbott, D and Ley, SC (2012)
IKK2 regulates TPL-2 activation of ERK-1/2 MAP kinases by direct phosphorylation of TPL-2 serine 400.
Molecular and Cellular Biology 32, 4684-4690 PubMed abstract
Yang, H-T; Papoutsopoulou, S; Belich, M; Brender, C; Janzen, J; Gantke, T; Handley, M and Ley, SC (2012)
Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.
Molecular and Cellular Biology 32, 3438-3451 PubMed abstract
Bi, Y; Zeng, N; Chanudet, E; Huang, Y; Hamoudi, RA; Liu, H; Dong, G; Watkins, AJ; Ley, SC; Zhou, L; Chen, R; Zhu, X and Du, MQ (2011)
A20 inactivation in ocular adnexal MALT lymphoma.
Haematologica 97, 926-930 PubMed abstract
Gantke, T; Sriskantharajah, S and Ley, SC (2011)
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.
Cell Research 21, 131-145 PubMed abstract
Gao, L; Coope, H; Grant, S; Ma, A; Ley, SC and Harhaj, EW (2011)
ABIN1 protein cooperates with TAX1BP1 and A20 to inhibit antiviral signaling.
Journal of Biological Chemistry 288, 36592-33660 PubMed abstract
Yang, H-T; Wang, Y; Zhao, X; Demissie, E; Papoutsopoulou, S; Mambole, A; O'Garra, A; Tomczak, MF; Erdman, SE; Fox, JG; Ley, SC and Horwitz, BH (2011)
NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation.
Journal of Immunology 186, 1989-1996 PubMed abstract
Mieulet, V; Yan, L; Choisy, C; Sully, K; Procter, J; Kouroumalis, A; Krywawych, S; Pende, M; Ley, SC; Moinard, C and Lamb, RF (2010)
TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.
Science Signaling 3, ra61 PubMed abstract
Sriskantharajah, S and Ley, SC (2010)
Turning off inflammation signaling.
Science 327, 1093-1094 PubMed abstract
Verstrepen, L; Verhelst, K; van Loo, G; Carpentier, I; Ley, SC and Beyaert, R (2010)
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
Biochemical Pharmacology 80, 2009-2020 PubMed abstract
Jacque, E and Ley, SC (2009)
RNF11, a new piece in the A20 puzzle.
EMBO Journal 28, 455-456 PubMed abstract
Kaiser, F; Cook, D; Papoutsopoulou, S; Rajsbaum, R; Wu, X; Yang, HT; Grant, S; Ricciardi-Castagnoli, P; Tsichlis, PN; Ley, SC and O'Garra, A (2009)
TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells.
Journal of Experimental Medicine 206, 1863-1871 PubMed abstract
Sriskantharajah, S; Belich, MP; Papoutsopoulou, S; Janzen, J; Tybulewicz, V; Seddon, B and Ley, SC (2009)
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation.
Nature Immunology 10, 38-47 PubMed abstract
Rousseau, S; Papoutsopoulou, M; Symons, A; Cook, D; Lucocq, JM; Prescott, AR; O'Garra, A; Ley, SC and Cohen, P (2008)
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNα in LPS-stimulated macrophages.
Journal of Cell Science 121, 149-154 PubMed abstract
Sun, S-C and Ley, SC (2008)
New insights into NF-κB regulation and function.
Trends in Immunology 29, 468-478 PubMed abstract