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Steve Ley Publications

Finney, BA; Schweighoffer, E; Navarro-Núñez, L; Bénézech, C; Barone, F; Hughes, CE; Langan, SA; Lowe, KL; Pollitt, AY; Mourao-Sa, D; Sheardown, S; Nash, GB; Smithers, N; Reis e Sousa, C; Tybulewicz, VLJ and Watson, SP (2012)
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Blood 119, 1747-1756 PubMed abstract
Gantke, T; Sriskantharajah, S; Sadowski, M and Ley, SC (2012)
IκB kinase regulation of the TPL-2/ERK MAPK pathway.
Immunological Reviews 246, 168-182 PubMed abstract
Bi, Y; Zeng, N; Chanudet, E; Huang, Y; Hamoudi, RA; Liu, H; Dong, G; Watkins, AJ; Ley, SC; Zhou, L; Chen, R; Zhu, X and Du, MQ (2011)
A20 inactivation in ocular adnexal MALT lymphoma.
Haematologica [Epub ahead of print] PubMed abstract
Gantke, T; Sriskantharajah, S and Ley, SC (2011)
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.
Cell Research 21, 131-145 PubMed abstract
Gao, L; Coope, H; Grant, S; Ma, A; Ley, SC and Harhaj, EW (2011)
ABIN1 protein cooperates with TAX1BP1 and A20 to inhibit antiviral signaling.
Journal of Biological Chemistry 288, 36592-33660 PubMed abstract
Yang, H-T; Wang, Y; Zhao, X; Demissie, E; Papoutsopoulou, S; Mambole, A; O'Garra, A; Tomczak, MF; Erdman, SE; Fox, JG; Ley, SC and Horwitz, BH (2011)
NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation.
Journal of Immunology 186, 1989-1996 PubMed abstract
Mieulet, V; Yan, L; Choisy, C; Sully, K; Procter, J; Kouroumalis, A; Krywawych, S; Pende, M; Ley, SC; Moinard, C and Lamb, RF (2010)
TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.
Science Signaling 3, ra61 PubMed abstract
Sriskantharajah, S and Ley, SC (2010)
Turning off inflammation signaling.
Science 327, 1093-1094 PubMed abstract
Verstrepen, L; Verhelst, K; van Loo, G; Carpentier, I; Ley, SC and Beyaert, R (2010)
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
Biochemical Pharmacology 80, 2009-2020 PubMed abstract
Jacque, E and Ley, SC (2009)
RNF11, a new piece in the A20 puzzle.
EMBO Journal 28, 455-456 PubMed abstract
Kaiser, F; Cook, D; Papoutsopoulou, S; Rajsbaum, R; Wu, X; Yang, HT; Grant, S; Ricciardi-Castagnoli, P; Tsichlis, PN; Ley, SC and O'Garra, A (2009)
TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells.
Journal of Experimental Medicine 206, 1863-1871 PubMed abstract
Sriskantharajah, S; Belich, MP; Papoutsopoulou, S; Janzen, J; Tybulewicz, V; Seddon, B and Ley, SC (2009)
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation.
Nature Immunology 10, 38-47 PubMed abstract
Rousseau, S; Papoutsopoulou, M; Symons, A; Cook, D; Lucocq, JM; Prescott, AR; O'Garra, A; Ley, SC and Cohen, P (2008)
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNα in LPS-stimulated macrophages.
Journal of Cell Science 121, 149-154 PubMed abstract
Sun, S-C and Ley, SC (2008)
New insights into NF-κB regulation and function.
Trends in Immunology 29, 468-478 PubMed abstract
Robinson, MJ; Beinke, S; Kouroumalis, PN; Tsichlis, PN and Ley, SC (2007)
Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.
Molecular and Cellular Biology 27, 7355-7364 PubMed abstract
Shirali, S; Hamoudi, RA; Bench, A; Scott, M; Ley, SC and Du, MQ (2007)
TPL-2 MEK kinase is not targeted by mutation in diffuse large B cell lymphoma and myeloid leukemia.
Leukemia Research 31, 1604-1607 PubMed abstract
Cockman, ME; Lancaster, DE; Stolze, IP; Hewitson, KS; McDonough, MA; Coleman, ML; Coles, CH; Yu, X; Hay, RT; Ley, SC; Pugh, CW; Oldham, NJ; Masson, N; Schofield, CJ and Ratcliffe, PJ (2006)
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Proceedings of the National Academy of Sciences of the United States of America 103, 14767-14772 PubMed abstract
Papoutsopoulou, S; Symons, A; Tharmalingham, T; Belich, MP; Kaiser, F; Kioussis, D; O'Garra, A; Tybulewicz, V and Ley, SC (2006)
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
Nature Immunology 7, 606-615 PubMed abstract
Parameswaran, N; Pao, CS; Leonhard, KS; Kang, DS; Kratz, M; Ley, SC and Benovic, JL (2006)
Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFκ B1 p105 and negatively regulate lipopolysaccharide ERK1/2 activation in macrophages.
Journal of Biological Chemistry 281, 34159-34170 PubMed abstract
Symons, A; Beinke, S and Ley, SC (2006)
MAP kinase kinase kinases and innate immunity.
Trends in Immunology 27, 40-48 PubMed abstract