Science for Health
Genome duplication and segregation are two fundamental processes in biology. We study the ways in which signal transduction regulates these events. A key component in eukaryotic chromosome metabolism is the ATR/ATM family of proteins. These evolutionarily conserved signal transduction proteins are involved in a number of chromosomal processes including DNA replication, recombination, and checkpoint regulation. Inactivation of these genes leads to cell death, genome instability, and meiotic dysfunction as well as the genetic disorders, Ataxia Telengiectasia (AT) and Seckle syndrome.
We use genetically tractable S. cerevisiae to study the molecular basis for the ATR/ATM functions. We found that inactivation of Mec1/Tel1, the budding yeast homologues of ATR/ATM, leads to chromosome breakage during proliferation and disruption of essential meiotic chromosomal processes. Currently, our research focuses on the roles of Mec1/Tel1 in meiotic recombination and fragile site stability. The results of our studies will provide insights into how disruption of these genes leads to failure of fundamental chromosomal processes.
© MRC National Institute for Medical Research
The Ridgeway, Mill Hill, London NW7 1AA