MRC National Institute for Medical Research, London
Science for Health
Paul Driscoll Biography
Paul Driscoll obtained a BA and DPhil in Chemistry at the University of Oxford. It was during the vacations of his first degree whilst working as a synthetic chemist in the medicinal chemistry laboratories of the Wellcome Foundation Ltd that he discovered the power of NMR spectroscopy to probe molecular structure. He obtained his doctorate by applying NMR to the electron transfer protein plastocyanin in the group of Allen Hill FRS.
He spent two years post-doctoral experience at the National Institutes of Health in the USA with Marius Clore and Angela Gronenborn, and one year back in Oxford with Iain Campbell FRS during which he was involved in the application of new multidimensional heteronuclear NMR methods to isotope-labelled proteins.
In 1990 he obtained a Royal Society University Research Fellowship that he transferred in 1994 to University College London and the Ludwig Institute for Cancer Research. There he collaborated with Mike Waterfield FRS on a variety of applications of NMR to signalling protein modules in phosphoinositide signalling pathways.
In 2004 he became Professor of Structural Biology at UCL and started a part-time secondment to the MRC National Institute for Medical Research, before joining the NIMR on a full-time basis in 2008.
Throughout his career Paul has been interested to apply NMR to probe the structure, dynamics and function of proteins. These applications have involved many disparate aspects of prokaryotic and eukaryotic biological systems, and have drawn him into multidisciplinary approaches to problems in structural biology including X-ray crystallography and mass spectrometry.
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