MRC National Institute for Medical Research, London
Science for Health
Paul Burgoyne Publications
- Decarpentrie, F; Vernet, N; Mahadevaiah, SK; Longepied, G; Streichemberger, E; Aknin-Seifer, I; Ojarikre, OA; Burgoyne, PS; Metzler-Guillemain, C and Mitchell, MJ (2012)
Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
Human Molecular Genetics [Epub ahead of print] PubMed abstract - Trent, S; Dennehy, A; Richardson, H; Ojarikre, OA; Burgoyne, PS; Humby, T and Davies, W (2012)
Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder.
Psychoneuroendocrinology 37, 221-229 PubMed abstract - Vernet, N; Mahadevaiah, SK; Ojarikre, OA; Longepied, G; Prosser, HM; Bradley, A; Mitchell, MJ and Burgoyne, PS (2011)
The Y-encoded gene Zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice.
Current Biology 21, 787-793 PubMed abstract - Cocquet, J; Ellis, PJI; Yamauchi, Y; Riel, JM; Karacs, TPS; Rattigan, Á; Ojarikre, OA; Affara, NA; Ward, MA and Burgoyne, PS (2010)
Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation.
Molecular Biology of the Cell 21, 3497-3505 PubMed abstract - Lopes, AM; Burgoyne, PS; Ojarikre, A; Bauer, J; Sargent, CA; Amorim, A and Affara, NA (2010)
Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome.
BMC Genomics 11, 82 PubMed abstract - Royo, H; Polikiewicz, G; Mahadevaiah, SK; Prosser, H; Mitchell, M; Bradley, A; de Rooij, DG; Burgoyne, PS and Turner, JMA (2010)
Evidence that meiotic sex chromosome inactivation is essential for male fertility.
Current Biology 20, 2117-2123 PubMed abstract - Wijchers, PJ; Yandim, C; Panousopoulou, E; Ahmad, M; Harker, N; Saveliev, A; Burgoyne, PS and Festenstein, R (2010)
Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well.
Developmental Cell 19, 477-484 PubMed abstract - Yamauchi, Y; Riel, JM; Stoytcheva, Z; Burgoyne, PS and Ward, MA (2010)
Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage.
Genome Biology 11, R66 PubMed abstract - Burgoyne, PS; Mahadevaiah, SK and Turner, JMA (2009)
The consequences of asynapsis for mammalian meiosis.
Nature Reviews Genetics 10, 207-216 PubMed abstract - Cocquet, J; Ellis, PJ; Yamauchi, Y; Mahadevaiah, SK; Affara, NA; Ward, MA and Burgoyne, PS (2009)
The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.
PLoS Biology 7, e1000244 PubMed abstract - Davies, W; Humby, T; Kong, W; Otter, T; Burgoyne, PS and Wilkinson, LS (2009)
Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.
Biological Psychiatry 66, 360-367 PubMed abstract - Reynard, LN; Cocquet, J and Burgoyne, PS (2009)
The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.
Biology of Reproduction 81, 250-257 PubMed abstract - Yamauchi, Y; Riel, JM; Wong, SJ; Ojarikre, OA; Burgoyne, PS and Ward, MA (2009)
Live offspring from mice lacking the Y chromosome long arm gene complement.
Biology of Reproduction 81, 353-361 PubMed abstract - Chen, X; Watkins, R; Delot, E; Reliene, R; Schiestl, RH; Burgoyne, PS and Arnold, AP (2008)
Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes.
Developmental Neurobiology 68, 265-273 PubMed abstract - Mahadevaiah, SK; Bourc'his, D; de Rooij, DG; Bestor, TH; Turner, JMA and Burgoyne, PS (2008)
Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation.
Journal of Cell Biology 182, 263-276 PubMed abstract - Burgoyne, P (2007)
Anne McLaren 1927-2007 - Obituary.
Nature Genetics 39, 1041-1041 PubMed abstract - Burgoyne, PS; Mahadevaiah, SK and Turner, JMA (2007)
The management of DNA double-strand breaks in mitotic G2, and in mammalian meiosis viewed from a mitotic G2 perspective.
Bioessays 29, 974-986 PubMed abstract - Burgoyne, PS and Mitchell, MJ (2007)
The roles of mouse Y chromosome genes in spermatogenesis.
In: The Y Chromosome and Male Germ Cell Biology in Health and Diseases. Edited by Lau, Y-FC and Chan, WY.
Hackensack, NJ., World Scientific Publishers 2007. 1-25. - Davies, W; Humby, T; Isles, AR; Burgoyne, PS and Wilkinson, LS (2007)
X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder.
Biological Psychiatry 61, 1351-1360 PubMed abstract - Reynard, LN; Turner, JMA; Cocquet, J; Mahadevaiah, SK; Touré, A; Höög, C and Burgoyne, PS (2007)
Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR.
Biology of Reproduction 77, 329-335 PubMed abstract - Takada, Y; Isono, KI; Shinga, J; Turner, JMA; Kitamura, H; Ohara, O; Watanabe, G; Singh, PB; Kamijo, T; Jenuwein, T; Burgoyne, PS and Koseki, H (2007)
Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.
Development 134, 579-590 PubMed abstract - Turner, JMA and Burgoyne, PS (2007)
Male meiotic sex chromosome inactivation and meiotic silencing.
In: The Y Chromosome and Male Germ Cell Biology in Health and Diseases. Edited by Lau, YFC and Chan, WY.
Hackensack, NJ, World Scientific Publishers, 2007. 27-45. - Davies, W; Isles, AR; Burgoyne, PS and Wilkinson, LS (2006)
X-linked imprinting: effects on brain and behaviour.
Bioessays 28, 35-44 PubMed abstract - Gatewood, JD; Wills, A; Shetty, S; Xu, J; Arnold, AP; Burgoyne, PS and Rissman, EF (2006)
Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice.
Journal of Neuroscience 26, 2335-2342 PubMed abstract - Turner, JMA; Mahadevaiah, SK; Ellis, PJI; Mitchell, MJ and Burgoyne, PS (2006)
Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids.
Developmental Cell 10, 521-529 PubMed abstract - Ward, MA and Burgoyne, PS (2006)
The effects of deletions of the mouse Y chromosome long arm on sperm function - intracytoplasmic sperm injection (ICSI) - based analysis.
Biology of Reproduction 74, 652-658 PubMed abstract
[Page last updated 1 May 2012]
Burgoyne group
Recent publications
Research projects
- The role of Sly in sex chromosome repression and sperm development
- A Y short arm gene required for the apoptotic response to sex chromosome univalence
- A Y short arm gene required for sperm head elongation and formation of the sperm tail
- X-attached-Y/O males and the MI checkpoint response to univalent sex chromosomes
- Further studies of the causes of XYY male infertility
- The causes of XY female infertility
© MRC National Institute for Medical Research
The Ridgeway, Mill Hill, London NW7 1AA
Top of page