Molecular Structure

Heads of Division - Dr Steve Smerdon and Dr Steve Gamblin

Research in the Division focuses on the structure and function of protein and protein-nucleic acid assemblies that are involved in a variety of medically important disease processes. The Division currently consists of seven research groups, employing integrated X-ray crystallographic and NMR approaches as the principle methodologies for the determination of macromolecular structure and dynamics, and is fortunate to be closely associated with the MRC Biomedical NMR Centre that is equipped with state-of-the-art high field NMR facilities.

Our activities are further supported by a diversity of biophysical and biochemical techniques including mass spectroscopy, optical spectroscopy, analytical ultracentrifugation, binding and kinetic analysis, cryo-electron microscopy, single molecule methods and bioinformatics along with synthetic organic chemistry and chemical biology approaches, all available within the NIMR.

Clearly, our structural and biophysical data are most valuable when integrated with cell-biology, genetic analysis and biochemistry and we have established a wide-range of collaborations across the Institute and beyond in order to place our structural results in a broader biological and medical context.

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