MRC National Institute for Medical Research, London
Science for Health
Mike Blackman Publications
- Collins, CR; Das, S; Wong, EH; Andenmatten, N; Stallmach, R; Hackett, F; Herman, J-P; Müller, S; Meissner, M and Blackman, MJ (2013)
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Molecular Microbiology [Epub ahead of print] PubMed abstract - Deligianni, E; Morgan, RN; Bertuccini, L; Wirth, CC; Silmon de Monerri, NC; Spanos, L; Blackman, MJ; Louis, C; Pradel, G and Siden-Kiamos, I (2013)
A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes.
Cellular Microbiology [Epub ahead of print] PubMed abstract - Fulle, S; Withers-Martinez, C; Blackman, MJ; Morris, GM and Finn, PW (2013)
Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.
Journal of Chemical Information and Modeling [Epub ahead of print] PubMed abstract - Collins, CR and Blackman, MJ (2012)
Apicomplexan AMA1 in host cell invasion: a model at the junction?
Cell Host & Microbe 10, 531-533 PubMed abstract - Cruz, LN; Juliano, MA; Budu, A; Juliano, L; Holder, AA; Blackman, MJ and Garcia, CRS (2012)
Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
Malaria Journal 11, 69 PubMed abstract - da Cruz, LN; Juliano, MA; Budu, A; Juliano, L; Holder, AA; Blackman, MJ and Garcia, CRS (2012)
Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
Malaria Journal 11, PubMed abstract - Gemma, S; Giovani, S; Brindisi, M; Tripaldi, P; Brogi, S; Savini, L; Fiorini, I; Novellino, E; Butini, S; Campiani, G; Penzo, M and Blackman, MJ (2012)
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorganic & Medicinal Chemistry Letters 22, 5317-5321 PubMed abstract - Moon, RW; Hall, J; Rangkuti, F; Ho, YS; Almond, N; Mitchell, GH; Pain, A; Holder, AA and Blackman, MJ (2012)
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.
Proceedings of the National Academy of Sciences 110, 531-536 - Ruecker, A; Shea, M; Hackett, F; Suarez, C; Hirst, EMA; Milutinovic, K; Withers-Martinez, C and Blackman, MJ (2012)
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
Journal of Biological Chemistry 287, 37949-37963 PubMed abstract - Withers-Martinez, C; Suarez, C; Fulle, S; Kher, S; Penzo, M; Ebejer, J-P; Koussis, K; Hackett, F; Jirgensons, A; Finn, P and Blackman, MJ (2012)
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
International Journal for Parasitology 42, 597-612 PubMed abstract - Olivieri, A; Collins, CR; Hackett, F; Withers-Martinez, C; Marshall, J; Flynn, HR; Skehel, JM and Blackman, MJ (2011)
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.
PLOS Pathogens 7, e1002448 PubMed abstract - Santos, JM; Ferguson, DJP; Blackman, MJ and Soldati-Favre, D (2011)
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.
Science 331, 473-477 PubMed abstract - Silmon de Monerri, NC; Flynn, HR; Campos, MG; Hackett, F; Koussis, K; Withers-Martinez, C; Skehel, JM and Blackman, MJ (2011)
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.
Infection and Immunity 79, 1086-1097 PubMed abstract - Child, MA; Epp, C; Bujard, H and Blackman, MJ (2010)
Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth.
Molecular Microbiology 78, 187-202 PubMed abstract - Dvorin, JD; Martyn, DC; Patel, SD; Grimley, JS; Collins, CR; Hopp, CS; Bright, AT; Westenberger, S; Winzeler, E; Blackman, MJ; Baker, DA; Wandless, TJ and Duraisingh, MT (2010)
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.
Science 328, 910-912 PubMed abstract - Friedrich, N; Santos, JM; Liu, Y; Palma, AS; Leon, E; Saouros, S; Kiso, M; Blackman, MJ; Matthews, S; Feizi, T and Soldati-Favre, D (2010)
Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by Apicomplexan parasites.
Journal of Biological Chemistry 285, 2064-2076 PubMed abstract - Woehlbier, U; Epp, C; Hackett, F; Blackman, MJ and Bujard, H (2010)
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion.
Malaria Journal 9, 77 PubMed abstract - Collins, CR; Withers-Martinez, C; Hackett, F and Blackman, MJ (2009)
An inhibitory antibody blocks interactions between components of the malarial invasion machinery.
PLOS Pathogens 5, e1000273 PubMed abstract - Doerig, C; Baker, D; Billker, O; Blackman, MJ; Chitnis, C; Kumar, DS; Heussler, V; Holder, AA; Kocken, C; Krishna, S; Langsley, G; Lasonder, E; Menard, R; Meissner, M; Pradel, G; Ranford-Cartwright, L; Sharma, A; Sharma, P; Tardieux, T; Tatu, U and Alano, P (2009)
Signalling in malaria parasites.
Parasite 16, 169-182 PubMed abstract - Koussis, K; Withers-Martinez, C; Yeoh, S; Child, M; Hackett, F; Knuepfer, E; Juliano, L; Woehlbier, U; Bujard, H and Blackman, MJ (2009)
A multifunctional serine protease primes the malaria parasite for red blood cell invasion.
EMBO Journal 28, 725-735 PubMed abstract - Lazarou, M; Guevara Patiño, JA; Jennings, RM; McIntosh, RS; Shi, J; Howell, S; Cullen, E; Jones, T; Adame-Gallegos, JR; Chappel, JA; McBride, JS; Blackman, MJ; Holder, AA and Pleass, RJ (2009)
Inhibition of erythrocyte invasion and Plasmodium falciparum Merozoite Surface Protein 1 processing by human IgG1 and IgG3 antibodies.
Infection and Immunity 77, 5659-5667 PubMed abstract - Sajid, M; Blackman, MJ; Doyle, P; He, C; Land, KM; Lobo, C; Mackey, Z; Ndao, M; Reed, SL; Shiels, B; Swenerton, R and Weir, W (2009)
Proteases of parasitic protozoa - current status and validation.
In: Antiparasitic and antibacterial drug discovery: from molecular targets to drug candidates. Edited by Selzer, PM.
Wiley, 2009. 177-209. (Drug Discovery in Infectious Diseases, 1). - Wanyiri, JW; Techasintana, P; O'Connor, RM; Blackman, MJ; Kim, K and Ward, HD (2009)
Role of CpSUB1, a subtilisin-like protease in Cryptosporidium parvum infection in vitro.
Eukaryotic Cell 8, 470-477 PubMed abstract - Blackman, MJ (2008)
Malarial proteases and host cell egress: an 'emerging' cascade.
Cellular Microbiology 10, 1925-1934 PubMed abstract - Dowse, TJ; Koussis, K; Blackman, MJ and Soldati-Favre, D (2008)
Roles of proteases during invasion and egress by Plasmodium and Toxoplasma.
In: Molecular Mechanisms of Parasite Invasion. Edited by Burleigh, AB.
New York, Springer, 2008. 121-139. (Subcellular Biochemistry, - Sawmynaden, K; Saouros, S; Friedrich, N; Marchant, J; Simpson, P; Bleijlevens, B; Blackman, MJ; Soldati-Favre, D and Matthews, S (2008)
Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition.
EMBO Reports 9, 1149-1155 PubMed abstract - Withers-Martinez, C; Haire, LF; Hackett, F; Walker, PA; Howell, SA; Smerdon, SJ; Dodson, GG and Blackman, MJ (2008)
Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.
Journal of Molecular Biology 375, 773-781 PubMed abstract
[Page last updated 1 May 2013]
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