Science for Health
The key event during Mycobacterium tuberculosis infection is the ability of this pathogen to survive within phagosomes in host cells. This capability is linked to the aptitude of the live pathogen to manipulate the normal biology of the phagosome. The strategy by which M. tuberculosis manipulates the cellular trafficking machinery is multifactorial and complex. Although in vitro and in vivo studies have shed light into some aspects of tuberculosis pathogenesis, we still do not completely understand how M. tuberculosis manages to survive in eukaryotic cells and why host cells are in some cases able to eradicate this pathogen.
Our work aims to improve our understanding/ of how M. tuberculosis survive within host cells and, on the other hand, how do host cells kill mycobacteria under some conditions. Our research is focused in the characterization of novel host proteins involved in vesicular trafficking and the role of these proteins in phagosome dynamics and their involvement in immune responses against mycobacteria.
We believe that a deep understanding of the very fundamental biology of M. tuberculosis that considers its intracellular lifestyle is crucial for developing new therapies towards tuberculosis control.
© MRC National Institute for Medical Research
The Ridgeway, Mill Hill, London NW7 1AA