MRC National Institute for Medical Research, London
Science for Health
Lyle Zimmerman group project:
ENU phenotype movies
mh164 desert tad(dst) - circulation movie
bottom tail (wildtype) shows normal circulatory flow around the tail muscle, absent in dst tail (top)
mh164 desert tad (dst) - day 2 movie
dst embryos (top) show an enlarged heart, but heartbeat is relatively normal compared to wildtype (bottom).
mh164 desert tad(dst) - day 4 movie
dst embryos (left) show enlarged heart as well as a paucity of erythrocytes compared to wildtype (right)
mh19 mrs lot(mlo) movie
mrs lot tadpoles are paralyzed, and do not respond to tactile stimulus such as being touched with forceps.
mh44 petrified(pet) movie
petrified embryos fail to respond to tactile stimulus, such as being touched with forceps. Touching a wildtype outcrossed sibling embryo (top) elicits an escape response.
mh44 petrified(pet) heart movie
petrified tadpole (bottom) shows no heartbeat compared to wildtype embryo (top).
mh6 muzak(muz) movie
Wildtype embryo (top) shows beating heart; muzak embryo (bottom) shows no heartbeat.
mh114 cruella(cur) - day 3 movie
at N&F stage 37, cruella heartbeat is very weak.
mh114 cruella(cur) - wildtype day 3 movie
at N&F stage 37, wildtype embryos display a robust heartbeat.
mh114 cruella(cru) - cruella and diploid control - day 4 movie
Later stages show a small, abnormal, albeit beating heart, as well as substantial edema.
Zimmerman group
Recent publications
Research projects
- The frog Xenopus tropicalis
- Gynogenetic screens for chemically-induced mutations
- ENU phenotype database
- High throughput reverse genetics/TILLING
Resources
Gallery
- ENU phenotype movies
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