Luiz Pedro de Carvalho group

Mycobacterium tuberculosis systems and chemical biology

Our group focuses on the characterisation of important biological, biochemical and pharmacological processes at both the molecular and systems levels in Mycobacterium tuberculosis (Mtb).

One third of the world’s population is estimated to be infected by Mtb, the causative agent of human tuberculosis. At present, tuberculosis is the leading cause of death by a single bacterial pathogen worldwide, killing 2 million people yearly. Furthermore, a clear synergy exists between infection with Mtb and HIV/AIDS, underscoring the need for a deeper understanding of the disease process and the development of new treatments. Using basic and applied research (see below), our studies will lead to a better understanding of M. tuberculosis biochemistry, physiology and pathogenesis. This could lead to the development of novel approaches to treat tuberculosis in the future.

Students and postdoctoral fellows that join the lab will be trained on several aspects of molecular biology, mycobacteriology and infection biology, protein chemistry, mechanistic enzymology, inhibitor design and inhibition studies, spectroscopy, functional genomics, antibiotic research, bacterial physiology, and mass spectrometry-based metabolomics and proteomics.

Our research themes

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