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The structure of Nijmegen-breakage syndrome protein 1

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John Doorbar Publications

Borgogna, C; Zavattaro, E; De Andrea, M; Griffin, HM; Dell'Oste, V; Azzimonti, B; Landini, MM; Peh, WL; Pfister, H; Doorbar, J; Landolfo, S and Gariglio, M (2012)
Characterization of beta papillomavirus E4 expression in tumours from Epidermodysplasia Verruciformis patients and in experimental models.
Virology 423, 195-204 PubMed abstract
Isaacson Wechsler, E; Wang, Q; Roberts, I; Pagliarulo, E; Jackson, D; Untersperger, C; Coleman, N; Griffin, H and Doorbar, J (2012)
Reconstruction of human papillomavirus-16-mediated early-stage neoplasia implicates E6/E7 deregulation and the loss of contact inhibition in neoplastic progression.
Journal of Virology [Epub ahead of print]
Khan, J; Davy, CE; McIntosh, PB; Jackson, DJ; Hinz, S; Wang, Q and Doorbar, J (2011)
The role of calpain in the formation of HPV16 E1^E4 amyloid fibers and reorganization of the keratin network.
Journal of Virology 85, 9984-9997 PubMed abstract
Maglennon, GA; McIntosh, P and Doorbar, J (2011)
Persistence of viral DNA in the epithelial basal layer suggests a model for papillomavirus latency following immune regression.
Virology 414, 153-163 PubMed abstract
Nicolaides, L; Davy, C; Raj, K; Kranjec, C; Banks, L and Doorbar, J (2011)
Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance.
Virology 414, 137-145 PubMed abstract
Quint, W; Jenkins, D; Molijn, A; Struijk, L; van de Sandt, M; Doorbar, J; Mols, J; Van Hoof, C; Hardt, K; Struyf, F and Colau, B (2011)
One virus one lesion - individual components of CIN lesions contain a specific HPV type.
The Journal of Pathology [Epub ahead of print] PubMed abstract
Shigehara, K; Sasagawa, T; Doorbar, J; Kawaguchi, S; Kobori, Y; Nakashima, T; Shimamura, M; Maeda, Y; Miyagi, T; Kitagawa, Y; Kadono, Y; Konaka, H; Mizokami, A; Koh, E and Namiki, M (2011)
Etiological role of human papillomavirus infection for inverted papilloma of the bladder.
Journal of Medical Virology 83, 277-285 PubMed abstract
Ding, J; Doorbar, J; Li, B; Zhou, F; Gu, W; Zhao, L; Saunders, NA; Frazer, IH and Zhao, KN (2010)
Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes..
Virology 399, 46-58 PubMed abstract
Leong, CM; Doorbar, J; Nindl, I; Yoon, HS and Hibma, MH (2010)
Deregulation of E-cadherin by human papillomavirus is not confined to high-risk, cancer-causing types.
British Journal of Dermatology 163, 1253-1263 PubMed abstract
Leong, CM; Doorbar, J; Nindl, I; Yoon, H-S and Hibma, MH (2010)
Loss of epidermal Langerhans cells occurs in human papillomavirus α, γ, and μ but not β genus infections.
Journal of Investigative Dermatology 130, 472-480 PubMed abstract
McIntosh, PB; Laskey, P; Sullivan, K; Davy, C; Wang, Q; Jackson, DJ; Griffin, HM and Doorbar, J (2010)
E1^E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium.
Journal of Cell Science 123, 2810-2822 PubMed abstract
Shah, SD; Doorbar, J and Goldstein, RA (2010)
Analysis of host-parasite incongruence in papillomavirus evolution using importance sampling.
Molecular Biology and Evolution 27, 1301-1314 PubMed abstract
Davy, C; McIntosh, P; Jackson, DJ; Sorathia, R; Miell, M; Wang, Q; Khan, J; Soneji, Y and Doorbar, J (2009)
A novel interaction between the human papillomavirus type 16 E2 and E1^E4 proteins leads to stabilization of E2.
Virology 394, 266-275 PubMed abstract
Gammoh, N; Isaacson, E; Tomaic, V; Jackson, DJ; Doorbar, J and Banks, L (2009)
Inhibition of HPV-16 E7 oncogenic activity by HPV-16 E2.
Oncogene 28, 2299-2304 PubMed abstract
Wang, Q; Kennedy, A; Das, P; McIntosh, PB; Howell, SA; Isaacson, ER; Hinz, SA; Davy, C and Doorbar, J (2009)
Phosphorylation of the human papillomavirus type 16 E1^E4 protein at T57 by ERK triggers a structural change that enhances keratin binding and protein stability.
Journal of Virology 83, 3668-3683 PubMed abstract
McIntosh, PB; Martin, SR; Jackson, DJ; Khan, J; Isaacson, ER; Calder, L; Raj, K; Griffin, HM; Wang, Q; Laskey, P; Eccleston, JF and Doorbar, J (2008)
Structural analysis reveals an amyloid form of the HPV 16 E1^E4 protein and provides a molecular basis for its accumulation.
Journal of Virology 82, 8196-8203 PubMed abstract
Davy, C and Doorbar, J (2007)
G2/M cell cycle arrest in the life cycle of viruses.
Virology 368, 219-226 PubMed abstract
Doorbar, J (2007)
Papillomavirus life cycle organization and biomarker selection.
Disease Markers 23, 297-313 PubMed abstract
Doorbar, J and Griffin, H (2007)
Intrabody strategies for the treatment of human papillomavirus-associated disease.
Expert Opinion on Biological Therapy 7, 677-689 PubMed abstract
Doorbar, J and Raj, K (2007)
Biology of papillomavirus replication in infected epithelium.
Future Virology 2, 573-586
Davy, C and Doorbar, J (editors).
Human papillomaviruses: Methods and protocols.
Totowa, NJ, Humana Press, 2006.
Davy, CE; Ayub, M; Jackson, DJ; Das, P; McIntosh, P and Doorbar, J (2006)
HPV16 E1^E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm.
Virology 349, 230-244 PubMed abstract
Doorbar, J (2006)
Molecular biology of human papillomavirus infection and cervical cancer.
Clinical Science 110, 525-541 PubMed abstract
Fang, L; Budgeon, LR; Doorbar, J; Briggs, ER and Howett, MK (2006)
The human papillomavirus type 11 E1^E4 protein is not essential for viral genome amplification.
Virology 351, 271-279 PubMed abstract
Griffin, H; Elston, R; Jackson, D; Ansell, K; Coleman, M; Winter, G and Doorbar, J (2006)
Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting.
Journal of Molecular Biology 355, 360-378 PubMed abstract