Science for Health
Jean-Paul Vincent obtained his first degree in applied physics from the University of Louvain (Belgium). He then obtained a Fulbright fellowship for postgraduate studies in Biophysics at the University of California Berkeley (M.A and Ph.D.) His thesis showed that the dorso-ventral axis of frog embryos is specified by the so-called subcortical rotation in the egg.
From Berkeley, Jean-Paul moved across the bay to the University of California Medical Center in San Francisco for postdoctoral training with Patrick O’Farrell (as a Damon Runyon fellow). There, in collaboration with Tim Mitchison, he devised the first cell lineage tracer based on caged dye technology.
In 1993, he started his own research group at the Laboratory of Molecular Biology in Cambridge (UK) where he developed further his interests in epithelial patterning.
He moved to the National Institute for Medical Research in Mill Hill in 1997. There, he has shown that degradation of Wingless, an important signalling molecule is developmentally regulated and that such degradation is crucial in regulating the range of Wingless signalling. He continues to study the trafficking mechanisms that modulate the Wingless gradient. His most recent contribution concerns the interpretation of the Wingless gradient and the role of the gradient in growth control. Another area of active research concerns the signals that trigger apoptosis during epithelial development and homeostasis.
Jean-Paul is a member of British Society for Developmental Biology, the British Society for Cell Biology and the British Genetics Society. He was elected to EMBO in 2006. He sits on various review panels and scientific advisory committees. He co-founded Vastox, now Summit PLC.
© MRC National Institute for Medical Research
The Ridgeway, Mill Hill, London NW7 1AA