MRC National Institute for Medical Research, London

Jean Langhorne Publications

• Craig, AG; Grau, GE; Janse, C; Kazura, JW; Milner, D; Barnwell, JW; Turner, G and Langhorne, J (2012)
  The role of animal models for research on severe malaria.
  PLoS Pathogens 8, e1002401 PubMed abstract
• Freitas do Rosário, AP; Lamb, T; Spence, P; Stephens, R; Lang, A; Roers, A; Muller, W; O'Garra, A and Langhorne, J (2012)
  IL-27 promotes IL-10 production by effector Th1 CD4⁺ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
  Journal of Immunology 188, 1178-1190 PubMed abstract
• Lawton, J; Brugat, T; Yam, XY; Reid, A; Boehme, U; Otto, T; Pain, A; Jackson, A; Berriman, M; Cunningham, D; Preiser, P and Langhorne, J (2012)
  Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).
  BMC Genomics 13, [Epub ahead of print] PubMed abstract
• Adler, G; Steeg, C; Pfeffer, K; Murphy, TL; Murphy, KM; Langhorne, J and Jacobs, T (2011)
  B and T lymphocyte attenuator restricts the protective immune response against experimental malaria.
  Journal of Immunology 187, 5310-5319 PubMed abstract
• da Gloria Sousa, M; Reid, DM; Schweighoffer, E; Tybulewicz, V; Ruland, J; Langhorne, J; Yamasaki, S; Taylor, PR; Almeida, SR and Brown, GD (2011)
  Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
  Cell Host & Microbe 9, 436-443 PubMed abstract
• del Portillo, HA; Ferrer, M; Brugat, T; Martin-Jaular, L; Langhorne, J and Lacerda, MVG (2011)
  The role of the spleen in malaria.
  Cellular Microbiology 14, 343-355 PubMed abstract
• Langhorne, J; Buffet, P; Galinski, M; Good, M; Harty, J; Leroy, D; Mota, MM; Pasini, E; Renia, L; Riley, E; Stins, M and Duffy, P (2011)
  The relevance of non-human primate and rodent malaria models for humans.
  Malaria Journal 10, 1-4 PubMed abstract
• Nduati, E; Gwela, A; Karanja, H; Mugyenyi, C; Langhorne, J; Marsh, K and Urban, BC (2011)
  The plasma concentration of the B cell activating factor is increased in children with acute malaria.
  Journal of Infectious Diseases 204, 962-970
• Spence, PJ; Cunningham, D; Jarra, W; Lawton, J; Langhorne, J and Thompson, J (2011)
  Transformation of the rodent malaria parasite Plasmodium chabaudi.
  Nature Protocols 6, 553-561 PubMed abstract
• Stephens, R; Seddon, B and Langhorne, J (2011)
  Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria.
  PLoS ONE 6, e26686 PubMed abstract
• Tulone, C; Sponaas, AM; Raiber, EA; Tabor, AB; Langhorne, J and Chain, BM (2011)
  Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
  PLoS ONE 6, e24886 PubMed abstract
• Belyaev, NN; Brown, DE; Diaz, AIG; Rae, A; Jarra, W; Thompson, J; Langhorne, J and Potocnik, AJ (2010)
  Induction of an IL7-R⁺c-Kit^hi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria.
  Nature Immunology 11, 477-485 PubMed abstract
• Cunningham, D; Lawton, J; Jarra, W; Preiser, P and Langhorne, J (2010)
  The pir multigene family of Plasmodium: Antigenic variation and beyond.
  Molecular and Biochemical Parasitology 170, 65-73 PubMed abstract
• Fairlie-Clarke, KJ; Lamb, TJ; Langhorne, J; Graham, AL and Allen, JE (2010)
  Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity.
  BMC immunology 11, PubMed abstract
• Freitas do Rosario, AP; Langhorne, J; Duffy, PE and Finney, OC (2010)
  Recent advances in malaria research: new tools to understand an old enemy.
  Expert Review of Anti-infective Therapy 8, 863-866 PubMed abstract
• Nduati, EW; Ng, DHL; Ndungu, FM; Gardner, P; Urban, BC and Langhorne, J (2010)
  Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice.
  PLoS ONE 5, e15007 PubMed abstract
• Raiber, EA; Tulone, C; Zhang, Y; Martinez-Pomares, L; Steed, E; Sponaas, A; Langhorne, J; Noursadeghi, M; Chain, B and Tabor, AB (2010)
  Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.
  ACS Chemical Biology 5, 461-476 PubMed abstract
• Riley, EM; Couper, KN; Helmby, H; Hafalla, JCR; de Souza, JB; Langhorne, J; Jarra, W and Zavala, F (2010)
  Neuropathogenesis of human and murine malaria.
  Trends in Parasitology 26, 277-278 PubMed abstract
• Stephens, R and Langhorne, J (2010)
  Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria.
  PLoS Pathogens 6, e1001208 PubMed abstract
• Voisine, C; Mastelic, B; Sponaas, A-M and Langhorne, J (2010)
  Classical CD11c⁺ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria.
  International Journal for Parasitology 40, 711-719 PubMed abstract
• Blythe, JE; Niang, M; Marsh, K; Holder, AA; Langhorne, J and Preiser, PR (2009)
  Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates.
  Malaria Journal 8, 140 PubMed abstract
• Cunningham, D; Fonager, J; Jarra, W; Carret, C; Preiser, P and Langhorne, J (2009)
  Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?
  PLoS ONE 4, e4285 PubMed abstract
• Ndungu, FM; Cadman, ET; Coulcher, J; Nduati, E; Couper, E; Macdonald, DW; Ng, D and Langhorne, J (2009)
  Functional memory B cells and long-lived plasma cells are generated after a single Plasmodium chabaudi infection in mice.
  PLoS Pathogens 5, e1000690 PubMed abstract
• Okafor, CMF; Anumudu, CI; Omosun, YO; Uthaipibull, C; Ayede, I; Awobode, HO; Odaibo, AB; Langhorne, J; Holder, AA; Nwuba, RI and Troye-Blomberg, M (2009)
  Cellular responses to modified Plasmodium falciparum MSP1₁₉ antigens in individuals previously exposed to natural malaria infection.
  Malaria Journal 8, 263 PubMed abstract
• Saunders, A; Lamb, T; Pascall, J; Hutchings, A; Dion, C; Carter, C; Hepburn, L; Langhorne, J and Butcher, GW (2009)
  Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
  Malaria Journal 8, 53 PubMed abstract
• Sponaas, A-M; Freitas do Rosario, AP; Voisine, C; Mastelic, B; Thompson, J; Koernig, S; Jarra, W; Renia, L; Mauduit, M; Potocnik, AJ and Langhorne, J (2009)
  Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria.
  Blood 114, 5522-5531 PubMed abstract
• Stephens, R; Ndungu, FM and Langhorne, J (2009)
  Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells.
  Parasite Immunology 31, 20-31 PubMed abstract
• Blythe, JE; Yam, XY; Kuss, C; Bozdech, Z; Holder, AA; Marsh, K; Langhorne, J and Preiser, PR (2008)
  Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and locate to the surface membrane of infected red blood cells and the apical tip of merozoites.
  Infection and Immunity 76, 3329-3336 PubMed abstract
• Boraschi, D; Abebe Alemayehu, M; Aseffa, A; Chiodi, F; Chisi, J; Del Prete, G; Doherty, TM; Elhassan, I; Engers, H; Gyan, B; Harandi, AM; Kariuki, T; Kironde, F; Kouriba, B; Langhorne, J; Laskay, T; Medaglini, D; Olesen, O; Onyebujoh, P; Palma, C; Sauerwein, R; Sibanda, E; Steinhoff, U; Tagliabue, A; Thiel, A; Vahedi, M and Troye-Blomberg, M (2008)
  Immunity against HIV/AIDS, malaria, and tuberculosis during co-infections with neglected infectious diseases: Recommendations for the European Union research priorities.
  PLoS Neglected Tropical Diseases 2, e255 PubMed abstract
• Cadman, ET; Abdallah, AY; Voisine, C; Sponaas, A-M; Corran, P; Lamb, T; Brown, D; Ndungu, F and Langhorne, J (2008)
  Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, 9 or MyD88, and may affect antibody affinity.
  Infection and Immunity 76, 3924-3931 PubMed abstract
• Lamb, TJ and Langhorne, J (2008)
  The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites.
  Malaria Journal 7, 68 PubMed abstract
• Langhorne, J; Ndungu, FM; Sponaas, A-M and Marsh, K (2008)
  Immunity to malaria: more questions than answers.
  Nature Immunology 9, 725-732 PubMed abstract
• Achtman, AH; Stephens, R; Cadman, ET; Harrison, V and Langhorne, J (2007)
  Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi.
  Parasite Immunology 29, 435-444 PubMed abstract
• Clatworthy, MR; Willcocks, L; Urban, B; Langhorne, J; Williams, TN; Peshu, N; Watkins, NA; Floto, RA and Smith, KGC (2007)
  Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc γRIIb reduce susceptibility to malaria.
  Proceedings of the National Academy of Sciences of the United States of America 104, 7169-7174 PubMed abstract
• Fonager, J; Cunningham, D; Jarra, W; Koernig, S; Henneman, AA; Langhorne, J and Preiser, P (2007)
  Transcription and alternative splicing in the yir multigene family of the malaria parasite Plasmodium y. yoelii: Identification of motifs suggesting epigenetic and post-transcriptional control of RNA expression.
  Molecular and Biochemical Parasitology 156, 1-11 PubMed abstract
• Fonseca, L; Seixas, E; Butcher, G and Langhorne, J (2007)
  Cytokine responses of CD4⁺ T cells during a Plasmodium chabaudi chabaudi (ER) blood-stage infection in mice initiated by the natural route of infection.
  Malaria Journal 6, 77 PubMed abstract
• Lamb, TJ; Voisine, C; Koernig, S; Egan, CA; Harnett, W and Langhorne, J (2007)
  The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62.
  Parasite Immunology 29, 271-276 PubMed abstract
• Lamikanra, AA; Brown, D; Potocnik, A; Casals-Pascual, C; Langhorne, J and Roberts, DJ (2007)
  Malarial anemia: of mice and men.
  Blood 110, 18-28 PubMed abstract
• Lepenies, B; Gaworski, I; Tartz, S; Langhorne, J; Fleischer, B and Jacobs, T (2007)
  CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections.
  Microbes and Infection 9, 687-694 PubMed abstract
• Lamb, TJ; Brown, DE; Potocnik, AJ and Langhorne, J (2006)
  Insights into the immunopathogenesis of malaria using mouse models.
  Expert Reviews in Molecular Medicine 8, 1-22 PubMed abstract
• Ndungu, FM; Sanni, L; Urban, B; Stephens, R; Newbold, CI; Marsh, K and Langhorne, J (2006)
  CD4 T cells from malaria-nonexposed individuals respond to the CD36-binding domain of Plasmodium falciparum erythrocyte membrane protein-1 via an MHC class II-TCR-independent pathway.
  Journal of Immunology 176, 5504-5512 PubMed abstract
• Sponaas, AM; Cadman, ET; Voisine, C; Harrison, V; Boonstra, A; O'Garra, A and Langhorne, J (2006)
  Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells.
  Journal of Experimental Medicine 203, 1427-1433 PubMed abstract
• Stephens, R and Langhorne, J (2006)
  Priming of CD4⁺ T cells and development of CD4⁺ T cell memory; lessons for malaria.
  Parasite Immunology 28, 25-30 PubMed abstract

[Page last updated 1 May 2012]