MRC National Institute for Medical Research, London

Jean Langhorne Publications

• Roetynck, S; Olotu, A; Simam, J; Marsh, K; Stockinger, B; Urban, B and Langhorne, J (2013)
  Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.
  PLOS ONE 8, e55195 PubMed abstract
• Craig, AG; Grau, GE; Janse, C; Kazura, JW; Milner, D; Barnwell, JW; Turner, G and Langhorne, J (2012)
  The role of animal models for research on severe malaria.
  PLOS Pathogens 8, e1002401 PubMed abstract
• Freitas do Rosário, AP; Lamb, T; Spence, P; Stephens, R; Lang, A; Roers, A; Muller, W; O'Garra, A and Langhorne, J (2012)
  IL-27 promotes IL-10 production by effector Th1 CD4⁺ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
  Journal of Immunology 188, 1178-1190 PubMed abstract
• Freitas do Rosario, AP and Langhorne, J (2012)
  T cell-derived IL-10 and its impact on the regulation of host responses during malaria.
  International Journal for Parasitology 42, 549-555 PubMed abstract
• Lawton, J; Brugat, T; Yam, XY; Reid, A; Boehme, U; Otto, T; Pain, A; Jackson, A; Berriman, M; Cunningham, D; Preiser, P and Langhorne, J (2012)
  Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).
  BMC Genomics 13, 125 PubMed abstract
• Mastelic, B; Freitas do Rosario, AP; Veldhoen, M; Renauld, J-C; Jarra, W; Sponaas, A-M; Roetynck, S; Stockinger, B and Langhorne, J (2012)
  IL-22 protects against liver pathology and lethality of an experimental blood-stage malaria infection.
  Frontiers in Immunology 3, 00085 PubMed abstract
• Spence, PJ; Jarra, W; Levy, P; Nahrendorf, W and Langhorne, J (2012)
  Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi.
  Malaria Journal 11, 407 PubMed abstract
• Spence, PJ and Langhorne, J (2012)
  T cell control of malaria pathogenesis.
  Current Opinion in Immunology 24, 444-448 PubMed abstract
• Sponaas, A-M; Belyaev, N; Falck-Hansen, M; Potocnik, A and Langhorne, J (2012)
  Transient deficiency of dendritic cells results in lack of a Merozoite Surface Protein 1-specific CD4 T cell response during peak Plasmodium chabaudi blood-stage infection.
  Infection and Immunity 80, 4248-4256 PubMed abstract
• Adler, G; Steeg, C; Pfeffer, K; Murphy, TL; Murphy, KM; Langhorne, J and Jacobs, T (2011)
  B and T lymphocyte attenuator restricts the protective immune response against experimental malaria.
  Journal of Immunology 187, 5310-5319 PubMed abstract
• da Gloria Sousa, M; Reid, DM; Schweighoffer, E; Tybulewicz, V; Ruland, J; Langhorne, J; Yamasaki, S; Taylor, PR; Almeida, SR and Brown, GD (2011)
  Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
  Cell Host & Microbe 9, 436-443 PubMed abstract
• del Portillo, HA; Ferrer, M; Brugat, T; Martin-Jaular, L; Langhorne, J and Lacerda, MVG (2011)
  The role of the spleen in malaria.
  Cellular Microbiology 14, 343-355 PubMed abstract
• Langhorne, J; Buffet, P; Galinski, M; Good, M; Harty, J; Leroy, D; Mota, MM; Pasini, E; Renia, L; Riley, E; Stins, M and Duffy, P (2011)
  The relevance of non-human primate and rodent malaria models for humans.
  Malaria Journal 10, 1-4 PubMed abstract
• Nduati, E; Gwela, A; Karanja, H; Mugyenyi, C; Langhorne, J; Marsh, K and Urban, BC (2011)
  The plasma concentration of the B cell activating factor is increased in children with acute malaria.
  Journal of Infectious Diseases 204, 962-970
• Spence, PJ; Cunningham, D; Jarra, W; Lawton, J; Langhorne, J and Thompson, J (2011)
  Transformation of the rodent malaria parasite Plasmodium chabaudi.
  Nature Protocols 6, 553-561 PubMed abstract
• Stephens, R; Seddon, B and Langhorne, J (2011)
  Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria.
  PLOS ONE 6, e26686 PubMed abstract
• Tulone, C; Sponaas, AM; Raiber, EA; Tabor, AB; Langhorne, J and Chain, BM (2011)
  Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
  PLOS ONE 6, e24886 PubMed abstract
• Belyaev, NN; Brown, DE; Diaz, AIG; Rae, A; Jarra, W; Thompson, J; Langhorne, J and Potocnik, AJ (2010)
  Induction of an IL7-R⁺c-Kit^hi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria.
  Nature Immunology 11, 477-485 PubMed abstract
• Cunningham, D; Lawton, J; Jarra, W; Preiser, P and Langhorne, J (2010)
  The pir multigene family of Plasmodium: Antigenic variation and beyond.
  Molecular and Biochemical Parasitology 170, 65-73 PubMed abstract
• Fairlie-Clarke, KJ; Lamb, TJ; Langhorne, J; Graham, AL and Allen, JE (2010)
  Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity.
  BMC Immunology 11, PubMed abstract
• Freitas do Rosario, AP; Langhorne, J; Duffy, PE and Finney, OC (2010)
  Recent advances in malaria research: new tools to understand an old enemy.
  Expert Review of Anti-infective Therapy 8, 863-866 PubMed abstract
• Nduati, EW; Ng, DHL; Ndungu, FM; Gardner, P; Urban, BC and Langhorne, J (2010)
  Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice.
  PLOS ONE 5, e15007 PubMed abstract
• Raiber, EA; Tulone, C; Zhang, Y; Martinez-Pomares, L; Steed, E; Sponaas, A; Langhorne, J; Noursadeghi, M; Chain, B and Tabor, AB (2010)
  Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.
  ACS Chemical Biology 5, 461-476 PubMed abstract
• Riley, EM; Couper, KN; Helmby, H; Hafalla, JCR; de Souza, JB; Langhorne, J; Jarra, W and Zavala, F (2010)
  Neuropathogenesis of human and murine malaria.
  Trends in Parasitology 26, 277-278 PubMed abstract
• Stephens, R and Langhorne, J (2010)
  Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria.
  PLOS Pathogens 6, e1001208 PubMed abstract
• Voisine, C; Mastelic, B; Sponaas, A-M and Langhorne, J (2010)
  Classical CD11c⁺ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria.
  International Journal for Parasitology 40, 711-719 PubMed abstract
• Blythe, JE; Niang, M; Marsh, K; Holder, AA; Langhorne, J and Preiser, PR (2009)
  Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates.
  Malaria Journal 8, 140 PubMed abstract
• Cunningham, D; Fonager, J; Jarra, W; Carret, C; Preiser, P and Langhorne, J (2009)
  Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?
  PLOS ONE 4, e4285 PubMed abstract
• Ndungu, FM; Cadman, ET; Coulcher, J; Nduati, E; Couper, E; Macdonald, DW; Ng, D and Langhorne, J (2009)
  Functional memory B cells and long-lived plasma cells are generated after a single Plasmodium chabaudi infection in mice.
  PLOS Pathogens 5, e1000690 PubMed abstract
• Okafor, CMF; Anumudu, CI; Omosun, YO; Uthaipibull, C; Ayede, I; Awobode, HO; Odaibo, AB; Langhorne, J; Holder, AA; Nwuba, RI and Troye-Blomberg, M (2009)
  Cellular responses to modified Plasmodium falciparum MSP1₁₉ antigens in individuals previously exposed to natural malaria infection.
  Malaria Journal 8, 263 PubMed abstract
• Saunders, A; Lamb, T; Pascall, J; Hutchings, A; Dion, C; Carter, C; Hepburn, L; Langhorne, J and Butcher, GW (2009)
  Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
  Malaria Journal 8, 53 PubMed abstract
• Sponaas, A-M; Freitas do Rosario, AP; Voisine, C; Mastelic, B; Thompson, J; Koernig, S; Jarra, W; Renia, L; Mauduit, M; Potocnik, AJ and Langhorne, J (2009)
  Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria.
  Blood 114, 5522-5531 PubMed abstract
• Stephens, R; Ndungu, FM and Langhorne, J (2009)
  Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells.
  Parasite Immunology 31, 20-31 PubMed abstract
• Blythe, JE; Yam, XY; Kuss, C; Bozdech, Z; Holder, AA; Marsh, K; Langhorne, J and Preiser, PR (2008)
  Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and locate to the surface membrane of infected red blood cells and the apical tip of merozoites.
  Infection and Immunity 76, 3329-3336 PubMed abstract
• Boraschi, D; Abebe Alemayehu, M; Aseffa, A; Chiodi, F; Chisi, J; Del Prete, G; Doherty, TM; Elhassan, I; Engers, H; Gyan, B; Harandi, AM; Kariuki, T; Kironde, F; Kouriba, B; Langhorne, J; Laskay, T; Medaglini, D; Olesen, O; Onyebujoh, P; Palma, C; Sauerwein, R; Sibanda, E; Steinhoff, U; Tagliabue, A; Thiel, A; Vahedi, M and Troye-Blomberg, M (2008)
  Immunity against HIV/AIDS, malaria, and tuberculosis during co-infections with neglected infectious diseases: Recommendations for the European Union research priorities.
  PLoS Neglected Tropical Diseases 2, e255 PubMed abstract
• Cadman, ET; Abdallah, AY; Voisine, C; Sponaas, A-M; Corran, P; Lamb, T; Brown, D; Ndungu, F and Langhorne, J (2008)
  Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, 9 or MyD88, and may affect antibody affinity.
  Infection and Immunity 76, 3924-3931 PubMed abstract
• Lamb, TJ and Langhorne, J (2008)
  The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites.
  Malaria Journal 7, 68 PubMed abstract
• Langhorne, J; Ndungu, FM; Sponaas, A-M and Marsh, K (2008)
  Immunity to malaria: more questions than answers.
  Nature Immunology 9, 725-732 PubMed abstract

[Page last updated 1 May 2013]