MRC National Institute for Medical Research, London
Science for Health
Gitta Stockinger group project:
Role of the aryl hydrocarbon receptor and its ligands in Th17 mediated immune responses
Funded by an ERC Advanced Investigator grant we will screen AhR ligands ranging from exogenous toxins to endogenous physiological ligands for their effect on Th17 mediated immune responses and IL-22 production, define transcriptional changes in Th17 cells upon AhR ligation and test AhR involvement in inflammatory immune responses in vivo.
In collaboration with dermatologists at Kiel University we are assessing the role of AhR in human psoriasis as the involvement of IL-22 in psoriasis makes it highly likely that AhR plays a role in the pathogenesis of this disease.
Selected publications
- Stockinger, B (2009)
Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system.
Journal of Biology 8, 61 PubMed abstract - Veldhoen, M; Hirota, K; Westendorf, AM; Buer, J; Dumoutier, L; Renauld, J-C and Stockinger, B (2008)
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins.
Nature 453, 106-9 PubMed abstract - Veldhoen, M; Hirota, K; Christensen, J; O'Garra, A and Stockinger, B (2008)
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells.
Journal of Experimental Medicine 206, 43-49 PubMed abstract
Stockinger group
Recent publications
Research projects
- Plasticity of CD4 effector T cell development
- Modulation of immune responses by the aryl hydrocarbon receptor
- Role of the aryl hydrocarbon receptor and its ligands in Th17 mediated immune responses
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