MRC National Institute for Medical Research, London

François Guillemot Publications

• Pacary, E; Azzarelli, R and Guillemot, F (2013)
  Rnd3 coordinates early steps of cortical neurogenesis through actin-dependent and -independent mechanisms.
  Nature Communications 4, 1635 PubMed abstract
• Sun, W; Hu, X; Lim, MHK; Ng, CKL; Choo, SH; Castro, DS; Drechsel, D; Guillemot, F; Kolatkar, PR; Jauch, R and Prabhakar, S (2013)
  TherMos: estimating protein-DNA binding energies from in vivo binding profiles.
  Nucleic Acids Research [Epub ahead of print]
• Dajas-Bailador, F; Bonev, B; Garcez, P; Stanley, P; Guillemot, F and Papalopulu, N (2012)
  microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons.
  Nature Neuroscience 15, 697-699 PubMed abstract
• Diaz-Alonso, J; Aguado, T; Wu, C-S; Palazuelos, J; Hofmann, C; Garcez, P; Guillemot, F; Lu, H-C; Lutz, B; Guzman, M and Galve-Roperh, I (2012)
  The CB₁ cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis.
  Journal of Neuroscience 32, 16651-16665 PubMed abstract
• Hindley, C; Ali, F; McDowell, G; Cheng, K; Jones, A; Guillemot, F and Philpott, A (2012)
  Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation.
  Development 139, 1718-1723
• Martynoga, B; Drechsel, D and Guillemot, F (2012)
  Molecular control of neurogenesis: a view from the mammalian cerebral cortex.
  Cold Spring Harbor Perspectives in Biology 4, a008359 PubMed abstract
• Pacary, E; Haas, MA; Wildner, H; Azzarelli, R; Bell, DM; Abrous, DN and Guillemot, F (2012)
  Visualization and genetic manipulation of dendrites and spines in the mouse cerebral cortex and hippocampus using in utero electroporation.
  Journal of Visualized Experiments e4163 PubMed abstract
• Pacary, E; Martynoga, B and Guillemot, F (2012)
  Crucial first steps: the transcriptional control of neuron delamination.
  Neuron 74, 209-211 PubMed abstract
• Seibt, J; Armant, O; Le Digarcher, A; Castro, D; Ramesh, V; Journot, L; Guillemot, F; Vanderhaeghen, P and Bouschet, T (2012)
  Expression at the imprinted Dlk1-Gtl2 locus is regulated by proneural genes in the developing telencephalon.
  PLOS ONE 7, e48675 PubMed abstract
• Alfano, C; Viola, L; Heng, JI; Pirozzi, M; Clarkson, M; Flore, G; De Maio, A; Schedl, A; Guillemot, F and Studer, M (2011)
  COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.
  Development 138, 4685-4697 PubMed abstract
• Ali, F; Hindley, C; McDowell, G; Deibler, R; Jones, A; Kirschner, M; Guillemot, F and Philpott, A (2011)
  Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis.
  Development 138, 4267-4277 PubMed abstract
• Castro, DS and Guillemot, F (2011)
  Old and new functions of proneural factors revealed by the genome-wide characterization of their transcriptional targets.
  Cell Cycle 10, 4026-4031 PubMed abstract
• Castro, DS; Martynoga, B; Parras, C; Ramesh, V; Pacary, E; Johnston, C; Drechsel, D; Lebel-Potter, M; Garcia, LG; Hunt, C; Dolle, D; Bithell, A; Ettwiller, L; Buckley, N and Guillemot, F (2011)
  A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.
  Genes & Development 25, 930-945 PubMed abstract
• Dixit, R; Zimmer, C; Waclaw, RR; Mattar, P; Shaker, T; Kovach, C; Logan, C; Campbell, K; Guillemot, F and Schuurmans, C (2011)
  Ascl1 participates in Cajal-Retzius cell development in the neocortex.
  Cerebral Cortex 21, 2599-2611 PubMed abstract
• Ferrón, SR; Charalambous, M; Radford, E; McEwen, K; Wildner, H; Hind, E; Morante-Redolat, JM; Laborda, J; Guillemot, F; Bauer, SR; Fariñas, I and Ferguson-Smith, AC (2011)
  Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.
  Nature 475, 381-385 PubMed abstract
• Guillemot, F and Zimmer, C (2011)
  From cradle to grave: the multiple roles of fibroblast growth factors in neural development.
  Neuron 71, 574-588 PubMed abstract
• Hämmerle, B; Ulin, E; Guimera, J; Becker, W; Guillemot, F and Tejedor, FJ (2011)
  Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27^KIP1 expression and suppressing NOTCH signaling.
  Development 138, 2543-2554
• Marteau, L; Pacary, E; Valable, S; Bernaudin, M; Guillemot, F and Petit, E (2011)
  Angiopoietin-2 regulates cortical neurogenesis in the developing telencephalon.
  Cerebral Cortex 21, 1695-1702 PubMed abstract
• Onorati, M; Binetti, M; Conti, L; Camnasio, S; Calabrese, G; Albieri, I; Di Febo, F; Toselli, M; Biella, G; Martynoga, B; Guillemot, F; Consalez, GG and Cattaneo, E (2011)
  Preservation of positional identity in fetus-derived neural stem (NS) cells from different mouse central nervous system compartments.
  Cellular and Molecular Life Sciences 68, 1769-1783 PubMed abstract
• Pacary, E; Heng, J; Azzarelli, R; Riou, P; Castro, D; Lebel-Potter, M; Parras, C; Bell, DM; Ridley, AJ; Parsons, M and Guillemot, F (2011)
  Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling.
  Neuron 69, 1069-1084 PubMed abstract
• Pelling, M; Anthwal, N; McNay, D; Gradwohl, G; Leiter, AB; Guillemot, F and Ang, SL (2011)
  Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.
  Developmental Biology 349, 406-416 PubMed abstract
• Spella, M; Kyrousi, C; Kritikou, E; Stathopoulou, A; Guillemot, F; Kioussis, D; Pachnis, V; Lygerou, Z and Taraviras, S (2011)
  Geminin regulates cortical progenitor proliferation and differentiation.
  Stem Cells 29, 1269-1282 PubMed abstract
• Sudarov, A; Turnbull, RK; Kim, EJ; Lebel-Potter, M; Guillemot, F and Joyner, AL (2011)
  Ascl1 genetics reveals insights into cerebellum local circuit assembly.
  Journal of Neuroscience 31, 11055-11069
• Winpenny, E; Lebel-Potter, M; Fernandez, ME; Brill, MS; Gotz, M; Guillemot, F and Raineteau, O (2011)
  Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.
  Neural Development 6, 12 PubMed abstract
• Xie, Z; Chen, Y; Li, Z; Bai, G; Zhu, Y; Yan, R; Tan, F; Chen, YG; Guillemot, F; Li, L and Jing, N (2011)
  Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/β-catenin pathway.
  Proceedings of the National Academy of Sciences of the United States of America 108, 12119-11212 PubMed abstract
• Coppola, E; Rallu, M; Richard, J; Dufour, S; Riethmacher, D; Guillemot, F; Goridis, C and Brunet, J-F (2010)
  Epibranchial ganglia orchestrate the development of the cranial neurogenic crest.
  Proceedings of the National Academy of Sciences of the United States of America 107, 2066-2071 PubMed abstract
• Godin, JD; Colombo, K; Molina-Calavita, M; Keryer, G; Zala, D; Charrin, BC; Dietrich, P; Volvert, ML; Guillemot, F; Dragatsis, I; Bellaiche, Y; Saudou, F; Nguyen, L and Humbert, S (2010)
  Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.
  Neuron 67, 392-406 PubMed abstract
• Guillemot, F and Hobert, O (2010)
  Development.
  Current Opinion in Neurobiology 20, 2-5 PubMed abstract
• Sergaki, MC; Guillemot, F and Matsas, R (2010)
  Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1.
  Molecular and Cellular Neurosciences 44, 15-29 PubMed abstract
• Sheng, N; Xie, Z; Wang, C; Bai, G; Zhang, K; Zhu, Q; Song, J; Guillemot, F; Chen, YG; Lin, A and Jing, N (2010)
  Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.
  Proceedings of the National Academy of Sciences of the United States of America 107, 18886-18891 PubMed abstract
• Zimmer, C; Lee, J; Griveau, A; Arber, S; Pierani, A; Garel, S and Guillemot, F (2010)
  Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells.
  Development 137, 293-302 PubMed abstract
• Brill, MS; Ninkovic, J; Winpenny, E; Hodge, RD; Ozen, I; Yang, R; Lepier, A; Gascón, S; Erdelyi, F; Szabo, G; Parras, C; Guillemot, F; Frotscher, M; Berninger, B; Hevner, RF; Raineteau, O and Götz, M (2009)
  Adult generation of glutamatergic olfactory bulb interneurons.
  Nature Neuroscience 12, 1524-1533 PubMed abstract
• Geoffroy, CG; Critchley, JA; Castro, DS; Ramelli, S; Barraclough, C; Descombes, P; Guillemot, F and Raineteau, O (2009)
  Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues.
  Stem Cells 27, 847-856 PubMed abstract
• Grimaldi, P; Parras, C; Guillemot, F; Rossi, F and Wassef, M (2009)
  Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum.
  Developmental Biology 328, 422-433 PubMed abstract
• Jacob, J; Storm, R; Castro, DS; Milton, C; Pla, P; Guillemot, F; Birchmeier, C and Briscoe, J (2009)
  Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
  Development 136, 2477-2485 PubMed abstract
• Niquille, M; Garel, S; Mann, F; Hornung, J-P; Otsmane, B; Chevalley, S; Parras, C; Guillemot, F; Gaspar, P; Yanagawa, Y and Lebrand, C (2009)
  Transient neuronal populations are required to guide callosal axons: a role for Semaphorin 3C.
  PLOS Biology 7, e1000230 PubMed abstract
• Oishi, K; Watatani, K; Itoh, Y; Okano, H; Guillemot, F; Nakajima, K and Gotoh, Y (2009)
  Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
  Proceedings of the National Academy of Sciences of the United States of America 106, 13064-13069 PubMed abstract
• Pinto, L; Drechsel, D; Schmid, M-T; Ninkovic, J; Irmler, M; Brill, MS; Restani, L; Gianfranceschi, L; Cerri, C; Weber, SN; Tarabykin, V; Baer, K; Guillemot, F; Beckers, J; Zecevic, N; Dehay, C; Caleo, M; Schorle, H and Götz, M (2009)
  AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
  Nature Neuroscience 12, 1229-1237 PubMed abstract
• Roybon, L; Hjalt, T; Stott, S; Guillemot, F; Li, J-Y and Brundin, P (2009)
  Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis.
  PLOS ONE 4, e4779 PubMed abstract
• Skowronska-Krawczyk, D; Chiodini, F; Ebeling, M; Alliod, C; Kundzewicz, A; Castro, D; Ballivet, M; Guillemot, F; Matter-Sadzinski, L and Matter, J-M (2009)
  Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis.
  Development 136, 3767-3777 PubMed abstract
• Wang, B; Waclaw, RR; Allen, ZJ, 2nd; Guillemot, F and Campbell, K (2009)
  Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon.
  Neural Development 4, 5 PubMed abstract
• Woodhoo, A; Alonso, MB; Droggiti, A; Turmaine, M; D'Antonio, M; Parkinson, DB; Wilton, DK; Al-Shawi, R; Simons, P; Shen, J; Guillemot, F; Radtke, F; Meijer, D; Feltri, ML; Wrabetz, L; Mirsky, R and Jessen, KR (2009)
  Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity.
  Nature Neuroscience 12, 839-847 PubMed abstract
• Zhao, X; D' Arca, D; Lim, WK; Brahmachary, M; Carro, MS; Ludwig, T; Cardo, CC; Guillemot, F; Aldape, K; Califano, A; Iavarone, A and Lasorella, A (2009)
  The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
  Developmental Cell 17, 210-221 PubMed abstract
• Galichet, C; Guillemot, F and Parras, CM (2008)
  Neurogenin 2 has an essential role in development of the dentate gyrus.
  Development 135, 2031-2041 PubMed abstract
• Gohlke, JM; Armant, O; Parham, FM; Smith, MV; Zimmer, C; Castro, DS; Nguyen, L; Parker, JS; Gradwohl, G; Portier, CJ and Guillemot, F (2008)
  Characterization of the proneural gene regulatory network during mouse telencephalon development.
  BMC Biology 6, 15 PubMed abstract
• Heng, JI-T; Nguyen, L; Castro, DS; Zimmer, C; Wildner, H; Armant, O; Skowronska-Krawczyk, D; Bedogni, F; Matter, J-M; Hevner, R and Guillemot, F (2008)
  Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
  Nature 455, 114-118 PubMed abstract
• Mulder, J; Aguado, T; Keimpema, E; Barabás, K; Ballester Rosado, CJ; Nguyen, L; Monory, K; Marsicano, G; Di Marzo, V; Hurd, YL; Guillemot, F; Mackie, K; Lutz, B; Guzmán, M; Lu, H-C; Galve-Roperh, I and Harkany, T (2008)
  Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
  Proceedings of the National Academy of Sciences of the United States of America 105, 8760-8765 PubMed abstract
• Ribes, V; Stutzmann, F; Bianchetti, L; Guillemot, F; Dollé, P and Le Roux, I (2008)
  Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis.
  Developmental Biology 321, 470-481 PubMed abstract
• Sugimori, M; Nagao, M; Parras, CM; Nakatani, H; Lebel, M; Guillemot, F and Nakafuku, M (2008)
  Ascl1 is required for oligodendrocyte development in the spinal cord.
  Development 135, 1271-1281 PubMed abstract
• Zhao, X; Heng, JI-T; Guardavaccaro, D; Jiang, R; Pagano, M; Guillemot, F; Iavarone, A and Lasorella, A (2008)
  The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
  Nature Cell Biology 10, 643-653 PubMed abstract

[Page last updated 1 May 2013]