MRC National Institute for Medical Research, London

Science for Health

Ed Hulme Publications

Kaye, RG; Saldanha, JW; Lu, Z-L and Hulme, EC (2011)
Helix 8 of the M₁ muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site.
Molecular Pharmacology 79, 701-709
Hulme, EC and Trevethick, MA (2010)
Ligand binding assays at equilibrium: validation and interpretation.
British Journal of Pharmacology 161, 1219-1237 PubMed abstract
Lebon, G; Langmead, CJ; Tehan, BG and Hulme, EC (2009)
Mutagenic mapping suggests a novel binding mode for selective agonists of M₁ muscarinic acetylcholine receptors.
Molecular Pharmacology 75, 331-341 PubMed abstract
Bee, MS and Hulme, EC (2007)
Functional analysis of transmembrane domain 2 of the M₁ muscarinic acetylcholine receptor.
Journal of Biological Chemistry 282, 32471-32479 PubMed abstract
Goodwin, JA; Hulme, EC; Langmead, CJ and Tehan, BG (2007)
Roof and floor of the muscarinic binding pocket: Variations in the binding modes of orthosteric ligands.
Molecular Pharmacology 72, 1484-1496 PubMed abstract
Hulme, EC; Bee, MS and Goodwin, JA (2007)
Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors.
Biochemical Society Transactions 35, 742-745 PubMed abstract
Hulme, EC; Soper, AK; McLain, SE and Finney, JL (2006)
The hydration of the neurotransmitter acetylcholine in aqueous solution.
Biophysical Journal 91, 2371-2380 PubMed abstract