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Dimitrios Anastasiou Publications

Anastasiou, D (2013)
Metformin: a case of divide and conquer.
Breast Cancer Research 15, 306 PubMed abstract
Anastasiou, D and Cantley, LC (2012)
Breathless cancer cells get fat on glutamine.
Cell Research 22, 443-446 PubMed abstract
Anastasiou, D; Yu, Y; Israelsen, WJ; Jiang, JK; Boxer, MB; Hong, BS; Tempel, W; Dimov, S; Shen, M; Jha, A; Yang, H; Mattaini, KR; Metallo, CM; Fiske, BP; Courtney, KD; Malstrom, S; Khan, TM; Kung, C; Skoumbourdis, AP; Veith, H; Southall, N; Walsh, MJ; Brimacombe, KR; Leister, W; Lunt, SY; Johnson, ZR; Yen, KE; Kunii, K; Davidson, SM; Christofk, HR; Austin, CP; Inglese, J; Harris, MH; Asara, JM; Stephanopoulos, G; Salituro, FG; Jin, S; Dang, L; Auld, DS; Park, HW; Cantley, LC; Thomas, CJ and Vander Heiden, MG (2012)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nature Chemical Biology 8, 839-847 PubMed abstract
Garcia-Cao, I; Song, Min S; Hobbs, Robin M; Laurent, G; Giorgi, C; de Boer, Vincent CJ; Anastasiou, D; Ito, K; Sasaki, Atsuo T; Rameh, L; Carracedo, A; Vander Heiden, Matthew G; Cantley, Lewis C; Pinton, P; Haigis, Marcia C and Pandolfi, Pier P (2012)
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Cell 149, 49-62 PubMed abstract
Kalaitzidis, D; Sykes, Stephen M; Wang, Z; Punt, N; Tang, Y; Ragu, C; Sinha, Amit U; Lane, Steven W; Souza, Amanda L; Clish, Clary B; Anastasiou, D; Gilliland, DG; Scadden, David T; Guertin, David A and Armstrong, Scott A (2012)
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Cell Stem Cell 11, 429-439 PubMed abstract
Lyssiotis, CA; Anastasiou, D; Locasale, JW; Vander Heiden, MG; Christofk, HR and Cantley, LC (2012)
Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth .
Biomedical Research 23, SI 213-217
Anastasiou, D; Poulogiannis, G; Asara, JM; Boxer, MB; Jiang, J-K; Shen, M; Bellinger, G; Sasaki, AT; Locasale, JW; Auld, DS; Thomas, CJ; Vander Heiden, MG and Cantley, LC (2011)
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Science 334, 1278-1283 PubMed abstract
Locasale, JW; Grassian, AR; Melman, T; Lyssiotis, CA; Mattaini, KR; Bass, AJ; Heffron, G; Metallo, CM; Muranen, T; Sharfi, H; Sasaki, AT; Anastasiou, D; Mullarky, E; Vokes, NI; Sasaki, M; Beroukhim, R; Stephanopoulos, G; Ligon, AH; Meyerson, M; Richardson, AL; Chin, L; Wagner, G; Asara, JM; Brugge, JS; Cantley, LC and Vander Heiden, MG (2011)
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Nature Genetics 43, 869-874 PubMed abstract
Sasaki, AT; Carracedo, A; Locasale, JW; Anastasiou, D; Takeuchi, K; Kahoud, ER; Haviv, S; Asara, JM; Pandolfi, PP and Cantley, LC (2011)
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Science Signaling 4, ra13 PubMed abstract