MRC National Institute for Medical Research, London
Science for Health
Benedict Seddon group project:
Regulation of naïve and memory T cell homeostasis by IL-7
Signals from the IL-7R are essential for normal homeostasis of the peripheral T cell pool. Together with TCR signals, IL-7 promotes both survival and homeostatic proliferation of naïve T cells. While T cell memory can, in contrast, persist in the complete absence of TCR signalling, IL-7R signals remain vital for both CD8 and CD4 memory T cell maintenance. Using mice that inducibly express IL-7Rα chain together with IL-7 cytokine deficient hosts, we have examined the role of IL-7R signalling in homeostasis of naïve and memory T cells and investigated the molecular basis for IL-7 function in T cells.
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Conditional expression of IL-7Rα using the Tetracycline regulatory system
Selected publications
- Buentke, E; Mathiot, A; Tolaini, M; Di Santo, J; Zamoyska, R and Seddon, B (2006)
Do CD8 effector cells need IL-7R expression to become resting memory cells?
Blood 108, 1949-1956 PubMed abstract - Saini, M; Pearson, C and Seddon, B (2009)
Regulation of T cell-dendritic cell interactions by IL7 governs T cell activation and homeostasis.
Blood 113, 5793-5800 PubMed abstract - Kemp, RA; Pearson, CF; Cornish, GH and Seddon, BP (2010)
Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation.
Immunology and Cell Biology 88, 213-219 PubMed abstract
Seddon group
Recent publications
Research projects
- Regulation of naïve and memory T cell homeostasis by IL-7
- Control of T cell homeostasis by Zap70 dependent TCR signalling
- Mathematical modelling of homeostatic responses
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