MRC National Institute for Medical Research, London
Science for Health
Benedict Seddon Publications
- Pearson, C; Silva, A and Seddon, B (2012)
Exogenous amino acids Are essential for interleukin-7 induced CD8 T cell growth.
PLoS ONE 7, e33998 PubMed abstract - Pearson, C; Silva, A; Saini, M and Seddon, B (2011)
IL-7 determines homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo.
European Journal of Immunology 41, 3656-3666 PubMed abstract - Silva, A; Laranjeira, ABA; Martins, LR; Cardoso, BA; Demengeot, J; Yunes, JA; Seddon, B and Barata, JT (2011)
IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias.
Cancer Research 71, 4780-4789 PubMed abstract - Sinclair, C; Saini, M; van der Loeff, IS; Sakaguchi, S and Seddon, B (2011)
The long-term survival potential of mature T lymphocytes is programmed during development in the thymus.
Science Signaling 4, ra77 PubMed abstract - Stephens, R; Seddon, B and Langhorne, J (2011)
Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria.
PLoS ONE 6, e26686 PubMed abstract - Kemp, RA; Pearson, CF; Cornish, GH and Seddon, BP (2010)
Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activation.
Immunology and Cell Biology 88, 213-219 PubMed abstract - Saini, M; Sinclair, C; Marshall, D; Tolaini, M; Sakaguchi, S and Seddon, B (2010)
Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.
Science Signaling 3, ra23 PubMed abstract - Veldhoen, M and Seddon, B (2010)
Empowering T helper 17 cells in autoimmunity.
Nature Medicine 16, 166-168 PubMed abstract - White, AJ; Nakamura, K; Jenkinson, WE; Saini, M; Sinclair, C; Seddon, B; Narendran, P; Pfeffer, K; Nitta, T; Takahama, Y; Caamano, JH; Lane, PJL; Jenkinson, EJ and Anderson, G (2010)
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.
Journal of Immunology 185, 4769-4776 PubMed abstract - Gascoyne, DM; Long, E; Veiga-Fernandes, H; de Boer, J; Williams, O; Seddon, B; Coles, M; Kioussis, D and Brady, HJM (2009)
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.
Nature Immunology 10, 1118-U1199 PubMed abstract - Himoudi, N; Yan, M; Bouma, G; Morgenstern, D; Wallace, R; Seddon, B; Buddle, J; Eddaoudi, A; Howe, SJ; Cooper, N and Anderson, J (2009)
Migratory and antigen presentation functions of IFN-producing killer dendritic cells.
Cancer Research 69, 6598-6606 PubMed abstract - Saini, M; Pearson, C and Seddon, B (2009)
Regulation of T cell-dendritic cell interactions by IL7 governs T cell activation and homeostasis.
Blood 113, 5793-5800 PubMed abstract - Sriskantharajah, S; Belich, MP; Papoutsopoulou, S; Janzen, J; Tybulewicz, V; Seddon, B and Ley, SC (2009)
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation.
Nature Immunology 10, 38-47 PubMed abstract - Yates, A; Saini, M; Mathiot, A and Seddon, B (2008)
Mathematical modeling reveals the biological program regulating lymphopenia-induced proliferation.
Journal of Immunology 180, 1414-1422 PubMed abstract - Filby, A; Seddon, B; Kleczkowska, J; Salmond, R; Tomlinson, P; Smida, M; Lindquist, JA; Schraven, B and Zamoyska, R (2007)
Fyn regulates the duration of TCR engagement needed for commitment to effector function.
Journal of Immunology 179, 4635-4644 PubMed abstract - Buentke, E; Mathiot, A; Tolaini, M; Di Santo, J; Zamoyska, R and Seddon, B (2006)
Do CD8 effector cells need IL-7R expression to become resting memory cells?
Blood 108, 1949-1956 PubMed abstract - Coles, MC; Veiga-Fernandes, H; Foster, KE; Norton, T; Pagakis, SN; Seddon, B and Kioussis, D (2006)
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.
Proceedings of the National Academy of Sciences of the United States of America 103, 13457-13462 PubMed abstract - Seddon, B (2006)
When TCR tickling helps T cells survive.
Blood 108, 5
[Page last updated 1 May 2012]
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