MRC National Institute for Medical Research, London
Science for Health
Benedict Seddon group
Characterisation of T cell receptor and cytokine signals that regulate T cell homeostasis
The size of the immune system is subject to tight homeostatic control mechanisms that regulate lymphocyte production, survival and proliferation. These mechanisms help the immune system recover from environmental insults both naturally occurring, following infections, or artificially induced as a consequence of medical treatment. Dysregulation of these homeostatic mechanisms can result in lymphoproliferative disorders, autoimmunity and malignancy. T cell antigen receptor (TCR) and interleukin-7 receptor (IL-7R) derived signals are vital for both thymic production and peripheral maintenance of T cells. The principle aim of this programme is to better understand how signals from these two receptors regulate T cell homeostasis. We have used both existing and newly generated in vivo mouse models to address this aim, as well as developing novel mathematic methods of analysis to facilitate more quantitative investigations of homeostatic T cell responses.
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Production and homeostasis of T lymphocytes is regulated by signals from the T cell antigen receptor and cytokines
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