MRC National Institute for Medical Research, London

Anne O’Garra Publications

• Freitas do Rosário, AP; Lamb, T; Spence, P; Stephens, R; Lang, A; Roers, A; Muller, W; O'Garra, A and Langhorne, J (2012)
  IL-27 promotes IL-10 production by effector Th1 CD4⁺ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
  Journal of Immunology 188, 1178-1190 PubMed abstract
• Li, D; Romain, G; Flamar, A-L; Duluc, D; Dullaers, M; Li, X-H; Zurawski, S; Bosquet, N; Palucka, AK; Le Grand, R; O'Garra, A; Zurawski, G; Banchereau, J and Oh, S (2012)
  Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4⁺ T cells.
  Journal of Experimental Medicine 209, 109-121
• Loebbermann, J; Schnoeller, C; Thornton, H; Durant, L; Sweeney, NP; Schuijs, M; O'Garra, A; Johansson, C and Openshaw, PJ (2012)
  IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
  PLoS ONE 7, e32371 PubMed abstract
• Lowe, DM; Redford, PS; Wilkinson, RJ; O'Garra, A and Martineau, AR (2012)
  Neutrophils in tuberculosis: friend or foe?
  Trends in Immunology 33, 14-25 PubMed abstract
• Tattermusch, S; Skinner, JA; Chaussabel, D; Banchereau, J; Berry, MP; McNab, FW; O'Garra, A; Taylor, GP and Bangham, CRM (2012)
  Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.
  PLoS Pathogens 8, e1002480 PubMed abstract
• Gabryšová, L; Christensen, JR; Wu, X; Kissenpfennig, A; Malissen, B and O'Garra, A (2011)
  Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3⁺ regulatory T cells.
  European Journal of Immunology 41, 1242-1248 PubMed abstract
• McNab, FW; Berry, MPR; Graham, CM; Bloch, SAA; Oni, T; Wilkinson, KA; Wilkinson, RJ; Kon, OM; Banchereau, J; Chaussabel, D and O'Garra, A (2011)
  Programmed Death Ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis.
  European Journal of Immunology 41, 1941-1947 PubMed abstract
• McNab, FW; Rajsbaum, R; Stoye, JP and O'Garra, A (2011)
  Tripartite-motif proteins and innate immune regulation.
  Current Opinion in Immunology 23, 46-56 PubMed abstract
• Medzhitov, R; Shevach, EM; Trinchieri, G; Mellor, AL; Munn, DH; Gordon, S; Libby, P; Hansson, GK; Shortman, K; Dong, C; Gabrilovich, D; Gabrysova, L; Howes, A and O'Garra, A (2011)
  Highlights of 10 years of immunology in Nature Reviews Immunology.
  Nature Reviews Immunology 11, 693-702 PubMed abstract
• O'Garra, A; Gabryšová, L and Spits, H (2011)
  Quantitative events determine the differentiation and function of helper T cells.
  Nature Immunology 12, 288-294 PubMed abstract
• Redford, PS; Murray, PJ and O'Garra, A (2011)
  The role of IL-10 in immune regulation during M. tuberculosis infection.
  Mucosal Immunology 4, 261-270 PubMed abstract
• Wack, A; Openshaw, P and O' Garra, A (2011)
  Contribution of cytokines to pathology and protection in virus infection.
  Current Opinion in Virology 1, 184-195 PubMed abstract
• Yang, H-T; Wang, Y; Zhao, X; Demissie, E; Papoutsopoulou, S; Mambole, A; O'Garra, A; Tomczak, MF; Erdman, SE; Fox, JG; Ley, SC and Horwitz, BH (2011)
  NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation.
  Journal of Immunology 186, 1989-1996 PubMed abstract
• Berry, MPR; Graham, CM; McNab, FW; Xu, Z; Bloch, SAA; Oni, T; Wilkinson, KA; Banchereau, R; Skinner, J; Wilkinson, RJ; Quinn, C; Blankenship, D; Dhawan, R; Cush, JJ; Mejias, A; Ramilo, O; Kon, OM; Pascual, V; Banchereau, J; Chaussabel, D and O'Garra, A (2010)
  An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
  Nature 466, 973-977 PubMed abstract
• Redford, PS; Boonstra, A; Read, S; Pitt, J; Graham, C; Stavropoulos, E; Bancroft, GJ and O'Garra, A (2010)
  Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
  European Journal of Immunology 40, 2200-2210 PubMed abstract
• Saraiva, M and O'Garra, A (2010)
  The regulation of IL-10 production by immune cells.
  Nature Reviews Immunology 10, 170-181 PubMed abstract
• Berry, MPR; Graham, CM; Bloch, SJ; Oni, T; Wilkinson, KA; Wilkinson, RJ; Kon, OM; Banchereau, J; Chaussabel, D and O'Garra, A (2009)
  Systems biology approaches characterise the host response to tuberculosis.
  Thorax 64, A10-A13
• Kaiser, F; Cook, D; Papoutsopoulou, S; Rajsbaum, R; Wu, X; Yang, HT; Grant, S; Ricciardi-Castagnoli, P; Tsichlis, PN; Ley, SC and O'Garra, A (2009)
  TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells.
  Journal of Experimental Medicine 206, 1863-1871 PubMed abstract
• Kassiotis, G and O'Garra, A (2009)
  Establishing the follicular helper identity.
  Immunity 31, 450-452 PubMed abstract
• O'Garra, A and Murphy, KM (2009)
  From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T_H1 development.
  Nature Immunology 10, 929-932 PubMed abstract
• Saraiva, M; Christensen, JR; Veldhoen, M; Murphy, TL; Murphy, KM and O'Garra, A (2009)
  Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.
  Immunity 31, 209-219 PubMed abstract
• Veldhoen, M; Hirota, K; Christensen, J; O'Garra, A and Stockinger, B (2009)
  Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells.
  Journal of Experimental Medicine 206, 43-49 PubMed abstract
• Berry, MPR; Chaussabel, D; Kon, OM; Banchereau, J and O'Garra, A (2008)
  The identification of distinct gene expression profiles in latent and active tuberculosis.
  Thorax 63, A63-65
• Kassiotis, G and O'Garra, A (2008)
  Immunity benefits from a little suppression.
  Science 320, 1168-1169 PubMed abstract
• O'Garra, A; Barrat, FJ; Castro, AG; Vicari, A and Hawrylowicz, C (2008)
  Strategies for use of IL-10 or its antagonists in human disease.
  Immunological Reviews 223, 114-131 PubMed abstract
• O'Garra, A and Britton, WJ (2008)
  Cytokines in tuberculosis.
  In: Handbook of tuberculosis. Immunology and Cell Biology. Edited by Kaufman, SHE and Britton, WJ.
  Weinheim, Wiley-VCH 2008. 2, 185-225.
• O'Garra, A; Stockinger, B and Veldhoen, M (2008)
  Differentiation of human T_H-17 cells does require TGF-β.
  Nature Immunology 9, 588-590 PubMed abstract
• Rajsbaum, R; Stoye, JP and O'Garra, A (2008)
  Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells.
  European Journal of Immunology 38, 619-630 PubMed abstract
• Rousseau, S; Papoutsopoulou, M; Symons, A; Cook, D; Lucocq, JM; Prescott, AR; O'Garra, A; Ley, SC and Cohen, P (2008)
  TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNα in LPS-stimulated macrophages.
  Journal of Cell Science 121, 149-154 PubMed abstract
• O'Garra, A and Vieira, P (2007)
  T_H1 cells control themselves by producing interleukin-10.
  Nature Reviews Immunology 7, 425-428 PubMed abstract
• Vieira, P and O'Garra, A (2007)
  Regula'ten' the gut.
  Nature Immunology 8, 905-907 PubMed abstract
• Young, D and O'Garra, A (2007)
  Mycobacterium tuberculosis and its ability to resist immunity.
  Novartis Foundation Symposium 281, 169-177; discussion 177-180, 208-169 PubMed abstract
• Boonstra, A; Rajsbaum, R; Holman, M; Marques, R; Asselin-Paturel, C; Pereira, JP; Bates, EEM; Akira, S; Vieira, P; Liu, YJ; Trinchieri, G and O'Garra, A (2006)
  Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
  Journal of Immunology 177, 7551-7558 PubMed abstract
• Haque, A; Easton, A; Smith, D; O'Garra, A; Van Rooijen, N; Lertmemongkolchai, G; Titball, RW and Bancroft, GJ (2006)
  Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection.
  Journal of Infectious Diseases 193, 370-379 PubMed abstract
• Neighbors, M; Hartley, SB; Xu, XL; Castro, AG; Bouley, DM and O'Garra, A (2006)
  Breakpoints in immunoregulation required for Th1 cells to induce diabetes.
  European Journal of Immunology 36, 2315-2323 PubMed abstract
• Papoutsopoulou, S; Symons, A; Tharmalingham, T; Belich, MP; Kaiser, F; Kioussis, D; O'Garra, A; Tybulewicz, V and Ley, SC (2006)
  ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
  Nature Immunology 7, 606-615 PubMed abstract
• Rowland, CA; Lertmemongkolchai, G; Bancroft, A; Haque, A; Lever, MS; Griffin, KF; Jackson, MC; Nelson, M; O'Garra, A; Grencis, R; Bancroft, GJ and Lukaszewski, RA (2006)
  Critical cole of Type 1 cytokines in controlling initial infection with Burkholderia mallei.
  Infection and Immunity 74, 5333-5340 PubMed abstract
• Shoemaker, J; Saraiva, M and O'Garra, A (2006)
  GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4⁺ T cells.
  Journal of Immunology 176, 3470-3479 PubMed abstract
• Sponaas, AM; Cadman, ET; Voisine, C; Harrison, V; Boonstra, A; O'Garra, A and Langhorne, J (2006)
  Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells.
  Journal of Experimental Medicine 203, 1427-1433 PubMed abstract
• Xystrakis, E; Kusumakar, S; Boswell, S; Peek, E; Urry, Z; Richards, DF; Adikibi, T; Pridgeon, C; Dallman, M; Loke, T-K; Robinson, DS; Barrat, FJ; O'Garra, A; Lavender, P; Lee, TH; Corrigan, C and Hawrylowicz, CM (2006)
  Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
  Journal of Clinical Investigation 116, 146-155 PubMed abstract

[Page last updated 1 May 2012]