MRC National Institute for Medical Research, London

Annalisa Pastore Publications

• Adrover, M; Martorell, G; Martin, SR; Urosev, D; Konarev, PV; Svergun, DI; Daura, X; Temussi, P and Pastore, A (2012)
  The role of hydration in protein stability: comparison of the cold and heat unfolded states of Yfh1.
  Journal of Molecular Biology 417, 413-424 PubMed abstract
• Bridwell-Rabb, J; Iannuzzi, C; Pastore, A and Barondeau, DP (2012)
  Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.
  Biochemistry 51, 2506-2514 PubMed abstract
• Pastore, A and Temussi, PA (2012)
  The two faces of Janus: functional interactions and protein aggregation.
  Current Opinion in Structural Biology 22, 30-37 PubMed abstract
• Pauwels, K; Williams, TL; Morris, KL; Jonckheere, W; Vandersteen, A; Kelly, G; Schymkowitz, J; Rousseau, F; Pastore, A; Serpell, LC and Broersen, K (2012)
  Structural basis for increased toxicity of pathological Aβ₄₂:Aβ₄₀ ratios in Alzheimer's disease.
  Journal of Biological Chemistry 287, 5650-5660 PubMed abstract
• Rees, M; Gorba, C; de Chiara, C; Bui, TTT; Garcia-Maya, M; Drake, Alex F; Okazawa, H; Pastore, A; Svergun, D and Chen, Yu W (2012)
  Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.
  Biophysical Journal 102, 1608-1616 PubMed abstract
• Salamat, MK; Moudjou, M; Chapuis, J; Herzog, L; Jaumain, E; Béringue, V; Rezaei, H; Pastore, A; Laude, H and Dron, M (2012)
  The integrity of helix 2 helix 3 domain of PrP protein is not mandatory for prion replication.
  Journal of Biological Chemistry [Epub ahead of print] PubMed abstract
• Soler, N; Craescu, CT; Gallay, J; Frapart, YM; Mansuy, D; Raynal, B; Baldacci, G; Pastore, A; Huang, ME and Vernis, L (2012)
  A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S containing yeast protein Dre2.
  FEBS Journal [Epub ahead of print] PubMed abstract
• van den Boom, J; Heider, D; Martin, SR; Pastore, A and Mueller, JW (2012)
  3'-Phospho-adenosine-5'-phosphosulphate (PAPS) synthases - naturally fragile enzymes specifically stabilised by nucleotide binding.
  Journal of Biological Chemistry [Epub ahead of print]
• Broersen, K; Jonckheere, W; Rozenski, J; Vandersteen, A; Pauwels, K; Pastore, A; Rousseau, F and Schymkowitz, J (2011)
  A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease.
  Protein Engineering Design & Selection 24, 743-775 PubMed abstract
• Bullard, B and Pastore, A (2011)
  Regulating the contraction of insect flight muscle.
  Journal of Muscle Research and Cell Motility 32, 303-313 PubMed abstract
• Esposito, V; Musi, V; de Chiara, C; Veggi, D; Serruto, D; Scarselli, M; Kelly, G; Pizza, M and Pastore, A (2011)
  Structure of the C-terminal domain of NHBA, one of the main antigens of a novel vaccine against N. meningitidis.
  Journal of Biological Chemistry 286, 41767-41775 PubMed abstract
• Iannuzzi, C; Adinolfi, S; Howes, BD; Garcia-Serres, R; Clémancey, M; Latour, JM; Smulevich, G and Pastore, A (2011)
  The role of CyaY in iron sulfur cluster assembly on the E. coli IscU scaffold protein.
  PLoS ONE 6, e21992 PubMed abstract
• Martin, SR; Avella, G; Adrover, M; De Nicola, GF; Bullard, B and Pastore, A (2011)
  Binding properties of the calcium-activated F2 isoform of Lethocerus troponin C.
  Biochemistry 50, 1839-1847 PubMed abstract
• Martorell, G; Adrover, M; Kelly, G; Temussi, PA and Pastore, A (2011)
  A natural and readily available crowding agent: NMR studies of proteins in hen egg white.
  Proteins 79, 1408-1415
• Masino, L; Nicastro, G; Calder, L; Vendruscolo, M and Pastore, A (2011)
  Functional interactions as a survival strategy against abnormal aggregation.
  FASEB Journal 25, 45-54 PubMed abstract
• Masino, L; Nicastro, G; De Simone, A; Calder, L; Molloy, J and Pastore, A (2011)
  The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
  Biophysical Journal 100, 2033-2042 PubMed abstract
• Paoletti, F; Malerba, F; Kelly, G; Noinville, S; Lamba, D; Cattaneo, A and Pastore, A (2011)
  Conformational plasticity of proNGF.
  PLoS ONE 6, e22615 PubMed abstract
• Savoia, A; Pastore, A; De Rocco, D; Civaschi, E; Di Stazio, M; Bottega, R; Melazzini, F; Bozzi, V; Pecci, A; Magrin, S; Balduini, CL and Noris, P (2011)
  Clinical and genetic aspects Bernard-Soulier syndrome: searching for genotype/phenotype correlations.
  Haematologica 96, 417-423 PubMed abstract
• Sjekloca, L; Pauwels, K and Pastore, A (2011)
  On the aggregation properties of FMRP: A link with the FXTAS syndrome?
  FEBS Journal 278, 1912-1921 PubMed abstract
• Xu, Z; Adrover, M; Pastore, A; Prigent, S; Mouthon, F; Comoy, E; Rezaei, H and Deslys, J-P (2011)
  Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain.
  FASEB Journal 25, 3426-3435
• Adrover, M; Esposito, V; Martorell, G; Pastore, A and Temussi, PA (2010)
  Understanding cold denaturation: the case study of Yfh1.
  Journal of the American Chemical Society 135, 16240-16246 PubMed abstract
• Adrover, M; Pauwels, K; Pringent, S; de Chiara, C; Xu, Z; Chapuis, C; Pastore, A and Rezaei, H (2010)
  Prion fibrillization is mediated by a native structural element which comprises the helices H2 and H3.
  Journal of Biological Chemistry 285, 21004-21012 PubMed abstract
• De Nicola, GF; Martin, S; Bullard, B and Pastore, A (2010)
  Solution structure of the apo C-terminal domain of the Lethocerus F1 troponin C isoform.
  Biochemistry 49, 1719-1726 PubMed abstract
• Di Bella, D; Lazzaro, F; Brusco, A; Plumari, M; Battaglia, G; Pastore, A; Finardi, A; Cagnoli, C; Tempia, F; Frontali, M; Veneziano, L; Sacco, T; Boda, E; Brussino, A; Bonn, F; Castellotti, B; Baratta, S; Mariotti, C; Gellera, C; Fracasso, V; Magri, S; Langer, T; Plevani, P; Di Donato, S; Muzi-Falconi, M and Taroni, F (2010)
  Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28.
  Nature Genetics 42, 313-321 PubMed abstract
• Esposito, V; Guglielmi, F; Martin, SR; Pauwels, K; Pastore, A; Piccoli, R and Temussi, PA (2010)
  Aggregation mechanisms of cystatins: a comparative study of monellin and orzacystatin.
  Biochemistry 49, 2805-2810 PubMed abstract
• Esposito, V; Musi, V; Veggi, D; Pastore, A and Pizza, M (2010)
  ¹H, ¹³C and ¹⁵N assignment of the C-terminal domain of GNA2132 from Neisseria meningitidis.
  Biomolecular NMR Assignments 4, 107-109 PubMed abstract
• Nicastro, G; Todi, SV; Karaca, E; Bonvin, AMJJ; Paulson, HL and Pastore, A (2010)
  Understanding the role of the Josephin domain in the polyUb binding and cleavage properties of ataxin-3.
  PLoS ONE 5, e12430 PubMed abstract
• Pastore, A (2010)
  Further insights into the ubiquitin pathway: understanding the scarlet letter code.
  Structure 18, 891-892 PubMed abstract
• Pecci, A; Panza, E; De Rocco, D; Pujol-Moix, N; Girotto, G; Podda, L; Paparo, C; Bozzi, V; Pastore, A; Balduini, CL; Seri, M and Savoia, A (2010)
  MYH9 related disease: four novel mutations of the tail domain of myosin-9 correlating with a mild clinical phenotype.
  European Journal of Haematology 84, 291-297 PubMed abstract
• Prischi, F; Konarev, PV; Iannuzzi, C; Pastore, C; Adinolfi, S; Martin, SR; Svergun, DI and Pastore, A (2010)
  Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly.
  Nature Communications 1, 95 PubMed abstract
• Prischi, F; Pastore, C; Carroni, M; Iannuzzi, C; Adinolfi, S; Temussi, P and Pastore, A (2010)
  Of the vulnerability of orphan complex proteins: The case study of the E. coli IscU and IscS proteins.
  Protein Expression and Purification 73, 161-166 PubMed abstract
• Rossetti, G; Magistrato, A; Pastore, A and Carloni, P (2010)
  Hydrogen bonding cooperativity in polyQ β-sheets from first principle calculations.
  Journal of Chemical Theory and Computation 6, 1777-1782
• Tapia, VE; Nicolaescu, E; McDonald, CB; Musi, V; Oka, T; Inayoshi, Y; Satteson, AC; Mazack, V; Humbert, J; Gaffney, CJ; Beullens, M; Schwartz, CE; Landgraf, C; Volkmer, R; Pastore, A; Farooq, A; Bollen, M and Sudol, M (2010)
  Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing.
  Journal of Biological Chemistry 285, 19391-19401 PubMed abstract
• Todi, SV; Scaglione, KM; Blount, JR; Basrur, V; Conlon, KP; Pastore, A; Elenitoba-Johnson, K and Paulson, HL (2010)
  Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
  Journal of Biological Chemistry 285, 39303-39313 PubMed abstract
• Adinolfi, S; Iannuzzi, C; Prischi, F; Pastore, C; Iametti, S; Martin, SR; Bonomi, F and Pastore, A (2009)
  Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS.
  Nature Structural & Molecular Biology 16, 390-396 PubMed abstract
• de Chiara, C; Menon, RP; Strom, M; Gibson, TJ and Pastore, A (2009)
  Phosphorylation of s776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.
  PLoS ONE 4, e8372 PubMed abstract
• de Rocco, D; Heller, PG; Girotto, G; Pastore, A; Glembotsky, AC; Marta, RF; Bozzi, V; Pecci, A; Molinas, FC and Savoia, A (2009)
  MYH9 related disease: a novel missense Ala95Asp mutation of the MYH9 gene.
  Platelets 20, 598-602 PubMed abstract
• Nicastro, G; Masino, L; Esposito, V; Menon, RP; De Simone, A; Fraternali, F and Pastore, A (2009)
  The josephin domain of ataxin-3 contains two distinct ubiquitin binding sites.
  Biopolymers 91, 1203-1214 PubMed abstract
• Pandolfo, M and Pastore, A (2009)
  The pathogenesis of Friedreich ataxia and the structure and function of frataxin.
  Journal of Neurology 256, 9-17 PubMed abstract
• Prischi, F; Giannini, C; Adinolfi, S and Pastore, A (2009)
  The N-terminus of mature human frataxin is intrinsically unfolded.
  FEBS Journal 276, 6669-6676 PubMed abstract
• Sanfelice, D; Tancredi, T; Politou, A; Pastore, A and Temussi, PA (2009)
  Cold denaturation and aggregation: a comparative NMR study of titin I28 in bulk and in a confined environment.
  Journal of the American Chemical Society 131, 11662-11663 PubMed abstract
• Sjekloca, L; Konarev, PV; Eccleston, J; Taylor, IA; Svergun, DI and Pastore, A (2009)
  A low resolution study of the ultrastructure of Fragile X related proteins.
  Biochemical Journal 419, 347-357 PubMed abstract
• Zen, A; de Chiara, C; Pastore, A and Micheletti, C (2009)
  Using dynamics-based comparisons to predict nucleic acid binding sites in proteins: an application to OB-fold domains.
  Bioinformatics 25, 1876-1883 PubMed abstract
• Correia, AR; Pastore, C; Adinolfi, S; Pastore, A and Gomes, CM (2008)
  Dynamics, stability and iron-binding activity of frataxin clinical mutants.
  FEBS Journal 275, 3680-3690 PubMed abstract
• de Chiara, C; Menon, RP and Pastore, A (2008)
  Structural bases for recognition of Anp32/LANP proteins.
  FEBS Journal 275, 2548-2560 PubMed abstract
• Ehrnhoefer, DE; Bieschke, J; Boeddrich, A; Herbst, M; Masino, L; Lurz, R; Engemann, S; Pastore, A and Wanker, EE (2008)
  EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
  Nature Structural & Molecular Biology 15, 558-566 PubMed abstract
• Martin, SR; Esposito, V; De Los Rios, P; Pastore, A and Temussi, PA (2008)
  Cold denaturation of yeast frataxin offers the clue to understand the effect of alcohols on protein stability.
  Journal of the American Chemical Society 130, 9963-9970 PubMed abstract
• Riess, O; Rüb, U; Pastore, A; Bauer, P and Schöls, L (2008)
  SCA3: Neurological features, pathogenesis and animal models.
  Cerebellum 7, 125-137 PubMed abstract
• Rossetti, G; Magistrato, A; Pastore, A; Persichetti, F and Carloni, P (2008)
  Structural properties of polyglutamine aggregates investigated via molecular dynamics simulations.
  Journal of Physical Chemistry B 112, 16843-16850 PubMed abstract
• De Chiara, C; Kelly, G; Frenkiel, TA and Pastore, A (2007)
  NMR assignment of the Leucine-Rich Repeat domain of LANP/Anp32a.
  Journal of Biomolecular NMR 38, 177 PubMed abstract
• De Filippis, V; Draghi, A; Frasson, R; Grandi, C; Musi, V; Fontana, A and Pastore, A (2007)
  o-Nitrotyrosine and p-iodophenylalanine as spectroscopic probes for structural characterization of SH3 complexes.
  Protein Science 16, 1257-1265 PubMed abstract
• De Nicola, G; Burkart, C; Qiu, F; Agianian, B; Labeit, S; Martin, S; Bullard, B and Pastore, A (2007)
  The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles.
  Structure 15, 813-824 PubMed abstract
• Foury, F; Pastore, A and Trincal, M (2007)
  Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly.
  EMBO Reports 8, 194-199 PubMed abstract
• Ivanova, EV; Kolosov, PM; Birdsall, B; Kelly, G; Pastore, A; Kisselev, LL and Polshakov, VI (2007)
  Eukaryotic class 1 translation termination factor eRF1 - the NMR structure and dynamics of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis.
  FEBS Journal 274, 4223-4237 PubMed abstract
• Klein, FAC; Pastore, A; Masino, L; Zeder-Lutz, G; Nierengarten, H; Oulad-Abdelghani, M; Altschuh, D; Mandel, J-L and Trottier, Y (2007)
  Pathogenic and non-pathogenic polyglutamine tracts have similar structural properties: Towards a length-dependent toxicity gradient.
  Journal of Molecular Biology 371, 235-244 PubMed abstract
• Pastore, A; Martin, SR; Politou, A; Kondapalli, KC; Stemmler, T and Temussi, PA (2007)
  Unbiased cold denaturation: low- and high-temperature unfolding of yeast frataxin under physiological conditions.
  Journal of the American Chemical Society 129, 5374-5375 PubMed abstract
• Pastore, A; Salvadori, S and Temussi, PA (2007)
  Peptides and proteins in a confined environment: NMR spectra at natural isotopic abundance.
  Journal of Peptide Science 13, 342-347 PubMed abstract
• Pastore, A and Zagari, A (2007)
  A structural overview of the vertebrate prion proteins.
  Prion 1, 185-197 PubMed abstract
• Pastore, C; Franzese, M; Sica, F; Temussi, P and Pastore, A (2007)
  Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin.
  FEBS Journal 274, 4199-4210 PubMed abstract
• Bal, NC; Agrawal, H; Meher, AK; Pulavarti, SVSRK; Jain, A; Kelly, G; Frenkiel, TA; Pastore, A and Arora, A (2006)
  NMR assignment of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis H37Rv.
  Journal of Biomolecular NMR 36, 53 PubMed abstract
• Bulone, D; Masino, L; Thomas, DJ; San Biagio, PL and Pastore, A (2006)
  The interplay between polyQ and protein context delays aggregation by forming a reservoir of protofibrils.
  PLoS ONE 1, e111, 111-110 PubMed abstract
• Correia, AR; Adinolfi, S; Pastore, A and Gomes, CM (2006)
  Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding.
  Biochemical Journal 398, 605-611 PubMed abstract
• Fiorin, G; Pastore, A; Carloni, P and Parrinello, M (2006)
  Using metadynamics to understand the mechanism of calmodulin/target recognition at atomic detail.
  Biophysical Journal 91, 2768-2777 PubMed abstract
• Menon, RP and Pastore, A (2006)
  Expansion of amino acid homo-sequences in proteins: Insights into the role of amino acid homo-polymers and of the protein context in aggregation.
  Cellular and Molecular Life Sciences 63, 1677-1685 PubMed abstract
• Musi, V; Birdsall, B; Fernandez-Ballester, G; Guerrini, R; Salvatori, S; Serrano, L and Pastore, A (2006)
  New approaches to high-throughput structure characterization of SH3 complexes: The example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae.
  Protein Science 15, 795-807 PubMed abstract
• Nicastro, G; Habeck, M; Masino, L; Svergun, DI and Pastore, A (2006)
  Structure validation of the Josephin domain of ataxin-3: Conclusive evidence for an open conformation.
  Journal of Biomolecular NMR 36, 267-277 PubMed abstract
• Pastore, C; Adinolfi, S; Huynen, MA; Rybin, V; Martin, S; Mayer, M; Bukau, B and Pastore, A (2006)
  YfhJ, a molecular adaptor in iron-sulfur cluster formation or a frataxin-like protein?
  Structure 14, 857-867 PubMed abstract
• Ramos, A; Hollingworth, D; Adinolfi, S; Castets, M; Kelly, G; Frenkiel, TA; Bardoni, B and Pastore, A (2006)
  The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction.
  Structure 14, 21-31 PubMed abstract

[Page last updated 1 May 2012]