MRC National Institute for Medical Research, London
Science for Health
Andreas Wack Publications
- Calabro, S; Tortoli, M; Baudner, BC; Pacitto, A; Cortese, M; O'Hagan, DT; De Gregorio, E; Seubert, A and Wack, A (2011)
Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes.
Vaccine 29, 1812-1823 PubMed abstract - Cantisani, R; Sammicheli, C; Tavarini, S; D'Oro, U; Wack, A and Piccioli, D (2011)
Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells.
Human immunology 72, 1018-1021 PubMed abstract - Seubert, A; Calabro, S; Santini, L; Galli, B; Genovese, A; Valentini, S; Aprea, S; Colaprico, A; D'Oro, U; Giuliani, MM; Pallaoro, M; Pizza, M; O'Hagan, DT; Wack, A; Rappuoli, R and De Gregorio, E (2011)
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.
Proceedings of the National Academy of Sciences of the United States of America 108, 11169-11174 PubMed abstract - Wack, A; Openshaw, P and O' Garra, A (2011)
Contribution of cytokines to pathology and protection in virus infection.
Current Opinion in Virology 1, 184-195 PubMed abstract - Crotta, S; Brazzoli, M; Piccioli, D; Valiante, NM and Wack, A (2010)
Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection.
Journal of Hepatology 52, 183-190 PubMed abstract - Pesce, I; Monaci, E; Muzzi, A; Tritto, E; Tavarini, S; Nuti, S; De Gregorio, E and Wack, A (2010)
Intranasal administration of CpG induces a rapid and transient cytokine response followed by dendritic and natural killer cell activation and recruitment in the mouse lung.
Journal of Innate Immunity 2, 144-159 PubMed abstract - Baudner, BC; Ronconi, V; Casini, D; Tortoli, M; Kazzaz, J; Singh, M; Hawkins, LD; Wack, A and O'Hagan, DT (2009)
MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).
Pharmaceutical Research 26, 1477-1485 PubMed abstract - De Gregorio, E; D'Oro, U and Wack, A (2009)
Immunology of TLR-independent vaccine adjuvants.
Current Opinion in Immunology 21, 339-345 PubMed abstract - Gallorini, S; Berti, F; Mancuso, G; Cozzi, R; Tortoli, M; Volpini, G; Telford, JL; Beninati, C; Maione, D and Wack, A (2009)
Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides.
Proceedings of the National Academy of Sciences of the United States of America 106, 17481-17486 PubMed abstract - Piccioli, D; Sammicheli, C; Tavarini, S; Nuti, S; Frigimelica, E; Manetti, AGO; Nuccitelli, A; Aprea, S; Valentini, S; Borgogni, E; Wack, A and Valiante, NM (2009)
Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation.
Blood 113, 4232-4239 PubMed abstract - Shaw, CA; Otten, G; Wack, A; Palmer, GA; Mandl, CW; Mbow, ML; Valiante, N and Dormitzer, PR (2009)
Antibody affinity maturation and respiratory syncytial virus disease.
Nature Medicine 15, 725 PubMed abstract - Wack, A; Seubert, A and Hilleringmann, M (2009)
Novel vaccines: vaccines in the near and distant future.
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 52, 1083-1090 PubMed abstract - Schultze, V; D'Agosto, V; Wack, A; Novicki, D; Zorn, J and Hennig, R (2008)
Safety of MF59TM adjuvant.
Vaccine 26, 3209-3222 PubMed abstract - Serra, A; Nuti, S; Tavarini, S; Sammicheli, C; Rosa, D; Saletti, G; Soldaini, E; Abrignani, S and Wack, A (2008)
Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function.
Journal of Immunology 181, 174-185 PubMed abstract - Seubert, A; Monaci, E; Pizza, M; O'Hagan, DT and Wack, A (2008)
The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells.
Journal of Immunology 180, 5402-5412 PubMed abstract - Wack, A; Baudner, BC; Hilbert, AK; Manini, I; Nuti, S; Tavarini, S; Scheffczik, H; Ugozzoli, M; Singh, M; Kazzaz, J; Montomoli, E; Del Giudice, G; Rappuoli, R and O'Hagan, DT (2008)
Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.
Vaccine 26, 552-561 PubMed abstract - Wack, A and Gallorini, S (2008)
Bacterial polysaccharides with zwitterionic charge motifs: Toll-like receptor 2 agonists, T cell antigens, or both?
Immunopharmacology and Immunotoxicology 30, 761-770 PubMed abstract - Gallorini, S; Berti, F; Parente, P; Baronio, R; Aprea, S; D'Oro, U; Pizza, M; Telford, JL and Wack, A (2007)
Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs.
Journal of Immunology 179, 8208-8215 PubMed abstract - O'Hagan, DT; Wack, A and Podda, A (2007)
MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans: what did we learn during its development?
Clinical Pharmacology and Therapeutics 82, 740-744 PubMed abstract - Piccioli, D; Tavarini, S; Borgogni, E; Steri, V; Nuti, S; Sammicheli, C; Bardelli, M; Montagna, D; Locatelli, F and Wack, A (2007)
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets.
Blood 109, 5371-5379 PubMed abstract - Tritto, E; Muzzi, A; Pesce, I; Monaci, E; Nuti, S; Galli, G; Wack, A; Rappuoli, R; Hussell, T and De Gregorio, E (2007)
The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature.
Journal of Immunology 179, 5346-5357 PubMed abstract - Crotta, S; Ronconi, V; Ulivieri, C; Baldari, Cosima T; Valiente, NM; Abrignani, S and Wack, A (2006)
Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells.
European Journal of Immunology 36, 919-929 PubMed abstract
[Page last updated 1 May 2012]
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