Andreas Wack group
Immune response to influenza
Seasonal influenza represents a constant burden to public health, and influenza pandemics caused by new virus strains pose a serious global threat. The influenza virus causes damage to the infected lung tissue and induces an immune response which is necessary to eliminate the virus but contributes to lung pathology. Which factors tip the balance between damage or death versus successful clearance of the virus with no long term damage is not completely known.
Our work aims to identify which features of the virus and host determine the outcome of disease. We focus on early events after infection, and in particular on the interface between the infected epithelium and the immune system. We have established a culture system of mouse airway epithelium and use this in co-culture with innate immune cells to dissect cellular cross-talk after infection with a variety of influenza virus strains. Complemented by in vivo studies, this approach will allow us to identify early events that pave the way for immune-mediated pathology or protection.
Mouse airway epithelial cultures stained with the tight junction protein ZO-1 (green) and the cilia constituent beta tubulin IV (magenta).
- Dittmann M, Hoffmann HH, Scull MA, Gilmore RH, Bell KL, Ciancanelli M, Wilson SJ, Crotta S, Yu Y, Flatley B, Xiao JW, Casanova JL, Wack A, Bieniasz PD, Rice CM. (2015)
A serpin shapes the extracellular environment to prevent influenza a virus maturation.
Cell Feb 12, 160(4):631-43. doi: 10.1016/j.cell.2015.01.040. PubMed abstract
- Davidson S, Crotta S, McCabe TM, Wack A. (2014)
Pathogenic potential of interferon αβ in acute influenza infection.
Nat Commun. 21;5, 3864. doi: 10.1038/ncomms4864. PubMed abstract
- Male V, Nisoli I, Kostrzewski T, Allan DS, Carlyle JR, Lord GM, Wack A, Brady HJ. (2014)
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
J Exp Med. 2014 Mar 24. [Epub ahead of print], PubMed abstract
- Crotta S, Gkioka A, Male V, Duarte JH, Davidson S, Nisoli I, Brady HJ, Wack A. (2014)
The Transcription Factor E4BP4 Is Not Required for Extramedullary Pathways of NK Cell Development.
J Immunol 15;192(6), 2677-88. doi: 10.4049/jimmunol.1302765. Epub 2014 Feb 17. PubMed abstract
- Crotta, S; Davidson, S; Mahlakoiv, T; Desmet, CJ; Buckwalter, MR; Albert, ML; Staeheli, P and Wack, A (2013)
Type I and Type III Interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia
PLOS Pathogens 9, e1003773 PubMed abstract
- Redford, PS; Mayer-Barber, KD; McNab, FW; Stavropoulos, E; Wack, A; Sher, A and O'Garra, A (2013)
Influenza A virus impairs control of Mycobacterium tuberculosis co-infection through a type I interferon receptor dependent pathway
Journal of Infectious Diseases , Epub ahead of print PubMed abstract
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