Science for Health
The Institute's research is organised in four major research areas, each with a number of specialised and interactive 'Divisions'.
Concerns the fundamental molecular and cell biology underlying embryo development, for which Dr David Wilkinson has overall responsibility.
Much of the research of the Divisions in this Group concerns the molecular mechanisms of embryonic development. The formation of an adult organism involves precise temporal and spatial control of the differentiation, movement and division of cells by a network of intercellular signals, intracellular signal transducers and transcription factors.
To identify and dissect the roles of genes involved in these processes we use a variety of model systems (yeast, fruit fly, zebrafish, frog, chick and mouse), and genetic and transgenic technologies.
Looks at the molecular and ultrastructural basis of pathogenesis and cellular immunological responses. Joint Heads: Jonathan Stoye and Victor Tybulewicz.
The objectives of research within Infections and Immunity are to:
Analyses how the nervous system develops and how it functions, headed by Dr Vassilis Pachnis.
Research in Neurosciences investigates:
Concerned with relating the molecular architecture of biomolecules to their function, headed by Dr Justin Molloy.
Divisions within Structural Biology study the three dimensional structures and chemical reactions of a range of biologically active and medically important molecules. These include transmitters, hormones, intracellular messengers, molecular motors and molecules involved in the regulation of DNA and protein synthesis. The goal of the research is to determine structures of protein molecules and the interactions that confer specificity and activate their mechanisms. In these studies, biochemical and biophysical methods such as optical and mass spectrometry are allied to structural methods like NMR, X-ray crystallography and molecular modelling. Armed with this information, the mechanisms inside and outside the cell, through which biological processes are effected, can be analysed at the atomic and molecular levels.
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