The developing hindbrain

Mass spectrometry

The Institute has two mass spectrometers which are used in a range of biochemical applications.

A research grade MALDITOF is primarily employed in proteomics studies, coupled with SDS-PAGE, to identify proteins from their peptide mass fingerprints by database searching. This instrument is also used to analyse peptide structure by post source decay fragmentation.

A quadrupole time-of-flight (Q-TOF) tandem mass spectrometer, equipped with electrospray and nanospray sources, is utilised for protein characterisation, peptide sequence confirmation and de novo sequencing. This instrument is also used in the investigation of post-translational modifications such as phosphorylation.

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