Molloy group ::

My group studies the mechanism of force production by molecular motors and also the way in which these proteins are regulated and targeted inside living cells. Our approach is to use a combination of single molecule methods and recombinant protein technologies to characterise and probe the functions of different motor proteins. Our work concentrates on studies of myosins, DNA processing enzymes, and small G-proteins.

Selected publications ::

• Mashanov GI, Tacon D, Knight AE, Peckham M, Molloy JE. (2003)
  Visualizing single molecules inside living cells using total internal reflection fluorescence microscopy.
  Methods 29:142-152
• Molloy, J.E. & Padgett, M.J. (2002)
  Lights, action: optical tweezers.
  Contemporary Physics 43, 241-258
• Veigel, C., Wang, F., Bartoo, M.L., Sellers, J.R. & Molloy, J.E. (2002)
  The gated gait of the processive molecular motor, myosin V.
  Nature Cell Biology 4, 59-65
• Ruegg, C. et al. (2002)
  Molecular motors: Force and movement generated by single myosin II molecules.
  News in Physiological Sciences 17, 213-218
• Wrobel, L.K. et al. (2002)
  Contractility of single human dermal myofibroblasts and fibroblasts.
  Cell Motility and the Cytoskeleton 52, 82-90
• Van Dijk, J., Knight, A.E., Molloy, J.E. & Chaussepied, P. (2002)
  Characterization of three regulatory states of the striated muscle thin filament.
  Journal of Molecular Biology 323, 475-489