MRC National Institute for Medical Research, London
Science for Health
Th17 paper becomes citation classic
05 February 2010
The paper was written by Marc Veldhoen and colleagues, from Gitta Stockinger's group in NIMR's Division of Molecular Immunology. At present, the paper ranks among the top 100 Highly Cited Papers in this field in Essential Science Indicators from Thomson Reuters, with 766 citations up to October 31, 2009. In the Web of Science®, this paper shows 837 citations.
This paper has offered new insights in both auto-immune disorders as well as infectious diseases. Genetic mutations have been identified impairing the development of human Th17 and have been associated with increased susceptibility to certain infections. Furthermore, genome-wide association studies have identified genes associated with Th17 biology, most notably the IL-23 receptor, which in addition to IL-17, is also targeted in numeral clinical trials
Marc Veldhoen
Original article
The classic paper is:
Veldhoen, M; Hocking, RJ; Atkins, CJ; Locksley, RM and Stockinger, B (2006)
TGFß in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Immunity 24, 179-89 PubMed abstract
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