MRC National Institute for Medical Research, London
Science for Health
News: research
The impact of endogenous retroviruses on antiviral immunity
11 May 2012
NIMR virologists and immunologists have shown that endogenous retroviruses can enhance antiviral immunity. The research is published in PLoS Pathogens.
Quantitative Biology Interest Group
08 May 2012
A new informal group at NIMR has been formed to bring together researchers at the Institute using quantitative techniques and computational methods to solve biological problems.
A new tool for protein functional analysis
01 May 2012
Scientists at NIMR have designed a mutant that eliminates nucleic acid binding by K-homology (KH) domains without destabilizing the KH fold, changing its structure or affecting KH–protein interactions. The research is published in Nucleic Acids Research.
Regulating the extension and branching of axons in the cerebral cortex
24 April 2012
Research published by scientists from the University of Manchester and from NIMR has uncovered a mechanism that controls axonal extension and branching. The work is published in Nature Neuroscience.
Automating the measurement of cell movements
23 April 2012
Scientists at NIMR have developed an improved way to measure cell movement. The research is published in Journal of Microscopy.
A drug target in the second most important cause of malaria
26 March 2012
A consortium of chemists, structural biologists and parasitologists has discovered a series of N-myristoyl transferase inhibitors and identified the features necessary for their novel mode of binding to the enzyme. The work is published in the Journal of Medicinal Chemistry.
An important meiotic quality control mechanism is not conserved in birds
09 March 2012
Research published by NIMR scientists has traced the evolution of a mechanism thought to be important in the elimination of germ cells with defective chromosome pairing. The work is published in PLoS Genetics.
A missing link between DNA repair and cell-cycle regulation
15 February 2012
A recent paper by NIMR scientists and collaborators in Oxford has revealed new molecular links between DNA double-stranded break repair and the cell-cycle machinery through interplay between the Rad51 recombinase, the Mre11/Rad50/Nbs1 complex and two important but poorly understood protein kinases. The research is published in Molecular Cell.
Mammalian forebrain interneurons maintain plasticity
07 February 2012
Scientists at NIMR have shown that interneurons of the mammalian forebrain, and perhaps many other neurons in the mammalian brain, maintain remarkable phenotypic plasticity. The research is published in PNAS.
T cells provide protective interleukin 10 in malaria infection
31 January 2012
Scientists at NIMR have uncovered the source of a critical molecule that helps to control immune–mediated pathology in malaria. The research is published in The Journal of Immunology, and is featured in the “In This Issue” section, among the top 10% of articles published in the journal.
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