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A drug target in the second most important cause of malaria
26 March 2012
A consortium of chemists, structural biologists and parasitologists has discovered a series of N-myristoyl transferase inhibitors and identified the features necessary for their novel mode of binding to the enzyme. The work is published in the Journal of Medicinal Chemistry.
An important meiotic quality control mechanism is not conserved in birds
09 March 2012
Research published by NIMR scientists has traced the evolution of a mechanism thought to be important in the elimination of germ cells with defective chromosome pairing. The work is published in PLoS Genetics.
Two new programmes in infectious disease
08 March 2012
Two new programme leaders track joined the Institute in 2011 to set up new research programmes.
A missing link between DNA repair and cell-cycle regulation
15 February 2012
A recent paper by NIMR scientists and collaborators in Oxford has revealed new molecular links between DNA double-stranded break repair and the cell-cycle machinery through interplay between the Rad51 recombinase, the Mre11/Rad50/Nbs1 complex and two important but poorly understood protein kinases. The research is published in Molecular Cell.
Mammalian forebrain interneurons maintain plasticity
07 February 2012
Scientists at NIMR have shown that interneurons of the mammalian forebrain, and perhaps many other neurons in the mammalian brain, maintain remarkable phenotypic plasticity. The research is published in PNAS.
T cells provide protective interleukin 10 in malaria infection
31 January 2012
Scientists at NIMR have uncovered the source of a critical molecule that helps to control immune–mediated pathology in malaria. The research is published in The Journal of Immunology, and is featured in the “In This Issue” section, among the top 10% of articles published in the journal.
Apply now for a Sandwich placement at NIMR
30 January 2012
We are now accepting applications for Sandwich placements for 2012-13. The closing date is Friday 24 February 2012.
A key developmental and stem cell regulator also acts in tumorigenesis
20 January 2012
Research published by NIMR scientists describes how a gene known to play a role in normal development and stem cells can contribute to the processes of transformation leading to cancer. The work is published in Cancer Research.
Gene network that builds tissues revealed
20 January 2012
A network of interacting genes that control how cells are organised into tissues has been revealed by scientists at NIMR and UCL. The research is published in Cell.
Quantitative imaging of metabolism: seeing is believing
20 January 2012
Researchers at NIMR and Harvard Medical School have developed a method for visualizing and quantitating the metabolism of molecules inside a single cell. The research is published in Nature.
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