Ogden group ::
Synaptic transmission and second messenger signalling
The interests of the lab are in the general areas of synaptic transmission and second messenger signalling, particularly control of:
The experimental approaches are the application of time resolved, high resolution electrophysiological and optical techniques to characterise mechanisms in excitability and secretion.
There is a long standing collaboration with John Corrie (Division of Physical Biochemistry) to develop and apply novel ‘caged’ neurotransmitters for localised photolysis in neurosience and to develop techniques for localisation. This approach permits investigation of the role of postsynaptic processes in changes of synaptic strength in brain tissue at the level of single synapses. It has yielded novel nitroindolinyl (NI- or MNI-) caged amino acid transmitters that have properties suitable for physiological studies with near-UV photolysis.