MRC National Institute for Medical Research, London
Science for Health
Postdoctoral scientist
Fluorescent biosensors: expanding range and uses
Division of Physical Biochemistry
Ref: IRC92690
We wish to identify an enthusiastic postdoctoral scientist to be appointed as a Career Development Fellow and to work with a high degree of independence in the group of Martin Webb. The project is largely funded by Medical Research Council Technology. The project involves development of novel reagentless biosensors for key molecules and to develop and exploit assays, incorporating such biosensors for probing important biological processes. Such biosensors have an important role in basic research, such as measuring the production and fate of target molecules, and in drug discovery. Our aim is develop research tools that can be exploited within our own work and by the wider scientific community. The project will encompass generation of mutant proteins, which interact specifically with the target molecule and so act as the recognition element. These are linked to a fluorescent moiety that is the reporter element. For a previous example, see ACS Chem. Biol. 5, 415. The project will lead to biochemical and biophysical characterization of the fluorescent protein, particularly using rapid reaction techniques, and application to a biological system.
The successful candidate will have a relevant PhD or be in the final stages of completing their PhD in biochemistry, biophysics, molecular biology or a related field. Knowledge of basic biochemical and biophysical techniques is essential, particularly experience working with proteins and basic molecular biology. Applicants should be able to learn quickly, have an interest in collaborative work, be able to communicate scientific ideas effectively. A high degree of enthusiasm to advance the project is essential for its successful outcome.
This is 2 years fixed term contract part - MRC part - externally funded.
Benefits
The salary range for this 2 year fixed-term Band 4 post is from £28,867 per annum inclusive of Location Allowance. Membership of MRC Final Salary Pension Scheme is available.
Additional benefits include 30 days annual leave per annum; options for flexible working; support for training and development; and good sport/social club facilities and staff restaurant.
Closing date: 23 May 2013
How to apply
Further details of this post may be found by following the 'Apply online' link below.
Your application, along with a covering letter and full CV, should be made online.
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Recruitment section contact details
Email: rcukjobs@ssc.rcuk.ac.uk or telephone 01793 867003, quoting reference IRC92690.
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